Deferoxamine retinopathy: spectral domain-optical coherence tomography findings
© Wu et al.; licensee BioMed Central Ltd. 2014
Received: 21 March 2014
Accepted: 26 June 2014
Published: 2 July 2014
To describe the spectral domain optical coherence tomography (SD-OCT) findings of a patient who developed pigmentary retinopathy following high-dose deferoxamine administration.
A 34-year-old man with thalassemia major complained of nyctalopia and decreased vision following high-dose intravenous deferoxamine to treat systemic iron overload. Fundus examination revealed multiple discrete hypo-pigmented lesions at the posterior pole and mid-peripheral retina. Recovery was partial following cessation of desferrioxamine six weeks later. A follow-up SD-OCT showed multiple accumulated hyper-reflective deposits primarily in the choroid, retina pigment epithelium (RPE), and inner segment and outer segment (IS/OS) junction.
Deferoxamine retinopathy primarily targets the RPE–Bruch membrane–photoreceptor complex, extending from the peri-fovea to the peripheral retina with foveola sparing. An SD-OCT examination can serve as a simple, noninvasive tool for early detection and long-term follow-up.
KeywordsSpectral domain optical coherence tomography Deferoxamine Retinopathy
Deferoxamine is an iron-chelating agent used to treat chronic iron overload in patients with thalassemia major and other hematologic conditions requiring routine blood transfusion [1, 2]. The incidence of deferoxamine-related ocular toxicity is approximately 1.2% based on a prior study . The clinical presentations may include night blindness, centrocaecal scotoma, constricted peripheral visual field, pigmentary retinopathy, and optic neuropathy . Retinal pigmentary change was most frequently reported . This case report pathologically characterizes the spectral domain optical coherence tomography (SD-OCT, SPECTRALIS SD-OCT, Heidelberg, Germany) and near-infrared reflectance (NIR) findings in a patient with deferoxamine retinopathy.
Deferoxamine is a widely used chelating agent in treating transfusional hemochromatosis [1, 5]. Visual symptoms included decreased visual acuity, night blindness, and colour vision abnormalities [2–6]. These ophthalmic examination findings have been reported extensively. Sumu et al. observed speckled hyper-fluorescence with well-demarcated areas of blocked fluorescence on fluorescein angiography . Markedly reduced photopic, scotopic, and 30-Hz flicker response amplitudes were reported on electroretinograms. Electro-oculogram typically showed reduced light-peak to dark-trough ratios [4, 6]. Viola et al. reported abnormal fundus autofluorescence in 9% of 197 patients, but only 5 patients reported visual symptoms . Viola et al. further described the pattern dystrophy–like or minimal changes of macular lesions in patients with deferoxamine retinopathy by using NIR and SD-OCT which pointed out the disease itself affects the RPE–Bruch membrane–photoreceptor complex .
The pathophysiology of deferoxamine-related retinopathy has been investigated for several years. Rahi et al. first reported electron microscopic findings of deferoxamine retinopathy, including patchy RPE depigmentation, abnormally thickened Bruch's membrane, and normal photoreceptors . Previous studies also discovered that iron overload and iron-chelating agents both may be mutually confounding factors in the causation of ocular changes of thalassemia such as RPE mottling [5, 10–13]. The SD-OCT findings in our case revealed multiple confluent hyper-reflective deposits in the RPE, IS/OS junction and choroid (Figure 3). We hypothesized that hyper-reflective deposits detected by means of SD-OCT may represent a primarily involvement of RPE–Bruch membrane–photoreceptor complex in deferoxamine toxicity which correlated with previous histologic findings [8, 9].
Ocular deferoxamine toxicity could cause vision impairment; regular ophthalmic assessment is required in these patients. We presented the SD-OCT findings of deferoxamine retinopathy highly correlated with previous histologic descriptions and showed that the toxicity primarily involved the RPE–Bruch membrane–photoreceptor complex. Noninvasive SD-OCT and NIR imaging, both well tolerated by patients, may be helpful in early detection and long-term monitoring.
The patient provided written informed consent for the publication of this case report and any accompanying images. A copy of the written consent is available for editorial review.
Spectral domain optical coherence tomography
Inner segment/outer segment
Retinal pigment epithelium.
The authors thank Dr. Chao-Ping Yang from the Department of Pediatrics, Chang Gung Memorial Hospital, in Taoyuan, Taiwan for her expertise in managing this patient.
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