Unilateral external ophthalmoplegia in Miller Fisher syndrome: case report
© Smith et al; licensee BioMed Central Ltd. 2007
Received: 13 November 2006
Accepted: 17 April 2007
Published: 17 April 2007
A description of the diagnostic features of Miller Fisher syndrome.
The clinical presentation, investigation, and subsequent progress of our patient with clinical unilateral external ophthalmoplegia.
Our case demonstrates the presentation of clinical unilateral external ophthalmoplegia as part of the full triad of Miller Fisher syndrome.
Miller Fisher syndrome was originally described in 1956 as a triad of total external ophthalmoplegia, ataxia and loss of tendon reflexes . Since the original description acute phase immunoglobulin G (IgG) antibodies to GQ1b ganglioside have been recognised as a serum marker for Miller Fisher syndrome . Anti GQ1b IgG antibodies are found in over 90% of cases of Miller Fisher syndrome and are highly disease specific . We report a case of a 32-year old gentleman with clinical unilateral external ophthalmoplegia in Miller Fisher syndrome confirmed by positive GQ1b antibody titre.
A 32-year old gentleman presented to the ophthalmic accident and emergency department with a four-day history of worsening horizontal and vertical diplopia. He denied any other ophthalmic or neurological symptoms at presentation. Other than a recent mild coryzal illness he was fit and well. He had no significant past ocular or medical history and took no regular medications.
A CT scan of his head with contrast showed no abnormality and the patient was transferred to the regional neurosciences centre for further investigation where the patient was found to be ataxic on heel to toe walk and the deep tendon reflexes were absent. Further investigation including an MRI, serology, lumbar puncture and Tensilon test were normal. Anti GQ1b IgG antibodies were positive with a significant titre by laboratory reference range, confirming the clinical diagnosis of Miller Fisher syndrome. With conservative management the patient's signs and symptoms resolved spontaneously within five weeks of presentation, leaving no permanent sequelae.
The marked asymmetry of the ophthalmoplegia in this case is unusual, and to our knowledge only a single previous report of a clinical unilateral external ophthalmoplegia as part of the full triad of Miller Fisher syndrome has been documented within the literature . Acute partial bilateral and unilateral ophthalmoparesis has been documented in association with anti GQ1b IgG antibodies, however these patients were not ataxic and the presence of deep tendon reflexes were variable , or neurological examination was normal .
This case demonstrates that uniocular external ophthalmoplegia can occur as part of the full triad in Miller Fisher syndrome. This reinforces the importance of considering systemic autoimmune diseases normally associated with bilateral ophthalmoparesis, in the differential diagnosis of a patient presenting with apparently unilateral signs.
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