Bilateral Morganella Morganii keratitis in a patient with facial topical corticosteroid-induced rosacea-like dermatitis: a case report
© The Author(s). 2017
Received: 8 February 2017
Accepted: 20 June 2017
Published: 28 June 2017
Bilateral keratitis rarely occurs in individuals without predisposing factors. Here we describe the clinical course of a patient who developed a bilateral keratitis caused by Morganella. morganii which might be associated with long term using of topical corticosteroids-containing preparations on the face.
A 52-year-old female patient presented with marked bilateral corneal infiltration and hypopyon without any usual predisposing factors for bilateral infectious keratitis. There was diffuse erythema with itching on face before the onset of eye discomforts. Microbiological culture of materials from both corneas revealed significant growth of Morganella morganii. Topical corticosteroid-induced rosacea-like dermatitis was diagnosed by dermatologist because of the characteristic eruptions and long history of using the corticosteroids-containing cosmetic creams on her face. The corneal ulcers responded well to levofloxacin eye drops and ofloxacin ointment and healed with opacity and neovascularization.
This case illustrates that bilateral bacterial corneal infection can develop in patients with long term using of topical corticosteroids-containing preparations on the face. To our knowledge, this is the first case of bilateral keratitis caused by Morganella morganii.
KeywordsBilateral Keratitis Morganella Morganii Corticosteroid Dermatitis
Bilateral keratitis usually occurs in predisposed individuals such as contact lens wearers, those suffering from malnutrition, immunodeficiency or patients undergoing bilateral refractive corneal surgery [1–3]. It has rarely been reported to develop in the absence of one of the predisposing factors mentioned above . Morganella morganii is a Gram negative bacillus which has been reported more commonly as a pathogen for panophthalmitis and orbital infection than the cause of corneal infection [5, 6]. We report here a case of bilateral bacterial keratitis caused by Morganella morganii developed in a healthy woman with facial topical corticosteroid-induced rosacea-like dermatitis.
The study was approved by the ethics committee of Sir Run Run Shaw hospital and the written informed consent for the publication of images was obtained from the patient.
Upon taking a more detailed history, the patient revealed that she had been using corticosteroids-containing cosmetic creams on the face for about 5 months and before that she had no eruptions on her face. The use of topical corticosteroid was suggested by her beauticians and the exact type was unknown. She had history of exacerbation of the eruptions following sun exposure and rebound phenomenon on stopping the cream. The patient was referred to dermatology outpatient department, where she was diagnosed with topical corticosteroid-induced rosacea-like dermatitis. Topical tacrolimus 0.03% dermatologic ointment (Protopic; Astellas Pharma, Tokyo, Japan) was prescribed for treatment.
In view of the unusual presentation, the patient was also investigated for evidence of immunosuppression and any systemic focus of infection. Human immunodeficiency virus serology was normal. Blood counts, blood sugar levels, liver and renal function tests were all within normal limits. Physical examinations and chest X-ray also failed to reveal any evidence of systemic disease. Serum vitamin A levels were not measured but the patient did not show any evidence of vitamin A deficiency. The patient was a housewife living in urban communities with good hygienic conditions and appeared to be in good health.
Bilateral infectious keratitis usually occurs in individuals with apparent risk factors, such as trauma, surgery, contact lens wearing or malnutrition [1–3]. There has only one report of bilateral keratitis caused by Pseudomonas aeruginosa developed in the absence of any obvious predisposing factor . Poor hygienic conditions, lack of clean water and high susceptibility to minor eye trauma while farming were the possible factors for that patient.
In the present case, the patient had none of the usual predisposing factors for bilateral infectious keratitis. We suspected that keratitis was associated with the topical corticosteroid-induced rosacea-like dermatitis which preceded the onset of corneal infection. Corticosteroid-induced rosacea is characterized by centrofacial, perioral, and periocular monomorphic inflammatory papules distributed in areas that have been chronically exposed to topical steroids, especially of fluorinated type . The skin has the appearance of rosacea-like eruptions and is rendered extremely vulnerable to bacterial, viral, and fungal infections. We presumed that long term application of corticosteroids around the eyelid could also lead to an immunocompromized state of the cornea in this patient. Minor corneal abrasions and secondary bacterial infection might be developed when she scratched the facial eruptions.
Topical corticosteroids are being misused widely on the face without a prescription from the dermatologists in China. Misuse of topical corticosteroids -containing preparations on the face and the adverse effects due to its application have been reported , but this is the first report of cornea infection in association with facial corticosteroids usages. We suggest that dispensing of corticosteroids must be regulated in China.
Morganella morganii is a Gram negative bacillus that belongs to the Enterobacteriaceae family and is considered as an unusual opportunistic pathogen that mainly causes post-operative wound and urinary tract infections . This species is a rare cause of ocular and periocular infections, such as endophthalmitis and orbital abscess [5, 6]. Only few case of keratitis secondary to Morganella morganii has been reported [10, 11]. In our case, Facial topical steroids might induce ocular immunosuppression, thus made corneas vulnerable to be infected by opportunistic pathogens. Morganella morganii is considered as a non-negligent opportunistic pathogen because of the increased levels of resistance and virulence. This organism is a related to genera Proteus and Providencia and has a unique antibiotic sensitivity profile with natural resistance to penicillins, some cephalosporins, macrolides, lincosamides and others. On the other hand, it is sensitive to some agents including aminoglycosides, piperacillin, third and fourth generation cephalosporins, carbapenems, and quinolones . In our case, the organism responded well to quinolones.
This case illustrates that bilateral bacterial corneal infection could develop in patient with long term using of topical corticosteroids-containing preparations on the face. To our knowledge, this is the first case of bilateral keratitis caused by Morganella morganii.
This work was supported partly by the National Natural Science Foundation of China (NSFC, No. 81100641) in the processing of the manuscript.
Availability of data and materials
All data supporting our findings are contained within the manuscript.
ZB collected, analyzed the data and carried out the writing of the manuscript. PF and ZKJ participated in the collection and interpretation of data. All authors read and approved the final manuscript.
Ethics approval and consent to participate
Consent for publication
Written informed consent was obtained from the patient for publication of this case report accompanying images. A copy of written consent is available for review by the Editor of this journal.
The authors declare that they have no competing interests.
Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
- Garg P, Bansal AK, Sharma S, Vemuganti GK. Bilateral infectious keratitis after laser in situ keratomileusis: a case report and review of literature. Ophthalmology. 2001;108:121–5.View ArticlePubMedGoogle Scholar
- Lipener C, Ribeiro AL. Bilateral pseudomonas corneal ulcer in a disposable contact lens wearer. CLAO J. 1999;25:123–4.PubMedGoogle Scholar
- Macsai MG, Agarwal G, Gamponia E. Bilateral corneal ulcer in primary vitamin a deficiency. Cornea. 1998;17:227–9.View ArticlePubMedGoogle Scholar
- Parmar P, Salman A, Kalavathy CM, Kaliamurthy J, Thomas PA, Nelson Jesudasan CA. Bilateral pseudomonas keratitis without predisposing factors. Indian J Ophthalmol. 2007;55:62–3.View ArticlePubMedGoogle Scholar
- Wang TJ, Huang JS, Hsueh PR. Acute postoperative Morganella morganii panophthalmitis. Eye. 2005;19:713–5.View ArticlePubMedGoogle Scholar
- Carruth BP, Wladis EJ. Orbital abscess from dacryocystitis caused by Morganella Morganii. Orbit. 2013;32:39–41.View ArticlePubMedGoogle Scholar
- Rathi SK, Kumrah L. Topical corticosteroid-induced rosacea-like dermatitis: a clinical study of 110 cases. Indian J Dermatol Venereol Leprol. 2011;77:42–6.View ArticlePubMedGoogle Scholar
- Saraswat A, Lahiri K, Chatterjee M, Barua S, Coondoo A, Mittal A, et al. Topical corticosteroid abuse on the face: a prospective, multicenter study of dermatology outpatients. Indian J Dermatol Venereol Leprol. 2011;77(2):160–6.View ArticlePubMedGoogle Scholar
- Liu H, Zhu J, Hu Q, Rao X. Morganella morganii, a non-negligent opportunistic pathogen. Int J Infect Dis. 2016;50:10–7.View ArticlePubMedGoogle Scholar
- Schaefer F, Bruttin O, Zografos L, Guex-Crosier Y. Bacterial keratitis: a prospective clinical and microbiological study. Br J Ophthalmol. 2001;85:842–7.View ArticlePubMedPubMed CentralGoogle Scholar
- Ray M, Nigel LC, Tan AM. Triple infection keratitis. Eye Contact Lens. 2014;40:123–6.View ArticlePubMedGoogle Scholar