Cornea and external eye diseases

Section edited by Penny Asbell

This section covers all aspects of corneal and external eye diseases, including surgical procedures, prevention, diagnosis and management. It also accepts basic science studies covering areas including, but not limited to, molecular and cellular biology, genetics and pathophysiology. Prospective clinical studies, especially randomized controlled trials are particularly welcome.

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  1. Case report

    In vivo confocal microscopy of pre-Descemet corneal dystrophy associated with X-linked ichthyosis: a case report

    Pre-Descemet corneal dystrophy (PDCD) is characterized by the presence of numerous, tiny, polymorphic opacities immediately anterior to Descemet membrane, which is a rare form of corneal stromal dystrophy and ...

    Hui Shi, Xiao-feng Qi, Tao-tao Liu, Qian Hao, Xiao-hong Li, Ling-ling Liang, Yi-miao Wang and Zhi-hua Cui

    BMC Ophthalmology 2017 17:29

    Published on: 16 March 2017

  2. Research article

    Analysis of novel Sjogren’s syndrome autoantibodies in patients with dry eyes

    Dry eye is a common problem in Ophthalmology and may occur for many reasons including Sjogren’s syndrome (SS). Recent studies have identified autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic ...

    Sandra Everett, Sahana Vishwanath, Vanessa Cavero, Long Shen, Lakshmanan Suresh, Kishore Malyavantham, Norah Lincoff-Cohen and Julian L. Ambrus

    BMC Ophthalmology 2017 17:20

    Published on: 7 March 2017

  3. Case report

    Corneal vesicles accumulate collagen VI associated with tissue remodeling in apolipoprotein a-I deficiency: a case report

    Apo A-I deficiency clinically shows low serum levels of HDL cholesterol and corneal opacity at a young age. Histopathological evaluations of affected corneas are not enough, and the mechanism of corneal opacit...

    Hiroyuki Namba, Mari Narumi, Shinji Susa, Rintaro Ohe, Takeo Kato, Mitsunori Yamakawa and Hidetoshi Yamashita

    BMC Ophthalmology 2017 17:11

    Published on: 8 February 2017

  4. Research article

    Microbiological profile of corneal ulcer cases diagnosed in a tertiary care ophthalmological institute in Nepal

    Corneal ulcer, a major cause of monocular blindness in developing countries has consistently been listed as the major cause of blindness and visual disability in many of the developing nations in Asia, Africa ...

    Sharmila Suwal, Dinesh Bhandari, Pratigya Thapa, Mohan Krishna Shrestha and Jyoti Amatya

    BMC Ophthalmology 2016 16:209

    Published on: 29 November 2016

  5. Research article

    Repertoire of free-living protozoa in contact lens solutions

    The repertoire of free-living protozoa in contact lens solutions is poorly known despite the fact that such protozoa may act as direct pathogens and may harbor intra-cellular pathogens.

    Ibtissem Bouchoucha, Aurore Aziz, Louis Hoffart and Michel Drancourt

    BMC Ophthalmology 2016 16:191

    Published on: 29 October 2016

  6. Research article

    Morphological changes in the meibomian glands of patients with phlyctenular keratitis: a multicenter cross-sectional study

    Phlyctenular keratitis is a hypersensitivity reaction of the cornea, and a complication of eyelid margin disease in children and young adults. In this study, we compared the morphology of the meibomian glands ...

    Takashi Suzuki, Naoyuki Morishige, Reiko Arita, Shizuka Koh, Tohru Sakimoto, Rika Shirakawa, Kazunori Miyata and Yuichi Ohashi

    BMC Ophthalmology 2016 16:178

    Published on: 10 October 2016

  7. Research article

    Estimation of axial curvature of anterior sclera: correlation between axial length and anterior scleral curvature as affected by angle kappa

    Though the development and fitting of scleral contact lenses are expanding steadily, there is no simple method to provide scleral metrics for scleral contact lens fitting yet. The aim of this study was to est...

    Sang-Mok Lee, Hyuk Jin Choi, Heejin Choi, Mee Kum Kim and Won Ryang Wee

    BMC Ophthalmology 2016 16:176

    Published on: 7 October 2016

  8. Research article

    Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial

    Dry eye disease (DED) is multifactorial, affecting 5–34 % of the global adult population and reducing quality of life. The artificial tears or lubricants are the therapy most used for the treatment of DED, due...

    Ana L. Pérez-Balbuena, Juan C. Ochoa-Tabares, Sandra Belalcazar-Rey, Cristian Urzúa-Salinas, Laura R. Saucedo-Rodríguez, Regina Velasco-Ramos, Raúl G. Suárez-Sánchez, Adolfo D. Rodríguez-Carrizalez and Aldo A. Oregón-Miranda

    BMC Ophthalmology 2016 16:164

    Published on: 20 September 2016

  9. Research article

    The effects of oral and topical corticosteroid in rabbit corneas

    To determine the most effective route of administration of corticosteroids in the treatment of ocular surface disease, by characterizing the difference between oral prednisolone and topical dexamethasone admin...

    Kaoru Araki-Sasaki, Osamu Katsuta, Hidetoshi Mano, Takashi Nagano and Masatsugu Nakamura

    BMC Ophthalmology 2016 16:160

    Published on: 5 September 2016

  10. Research article

    New histopathologic and ultrastructural findings in Reis-Bücklers corneal dystrophy caused by the Arg124Leu mutation of TGFBI gene

    Reis-Bücklers corneal dystrophy (RBCD) was consistently reported as a corneal dystrophy only affected Bowman’s layer and superficial corneal stroma, and superficial keratectomy was a recommendation surgery for...

    Wen-Ya Qiu, Li-Bin Zheng, Fei Pan, Bei-Bei Wang and Yu-Feng Yao

    BMC Ophthalmology 2016 16:158

    Published on: 2 September 2016

  11. Research article

    Visualization of precut DSAEK and pre-stripped DMEK donor corneas by intraoperative optical coherence tomography using the RESCAN 700

    To report the feasibility of intraoperative spectral domain optical coherence tomography (OCT) using the RESCAN 700 for the visualization and evaluation of precut Descemet’s stripping automated endothelial ker...

    Akira Kobayashi, Hideaki Yokogawa, Natsuko Mori and Kazuhisa Sugiyama

    BMC Ophthalmology 2016 16:135

    Published on: 4 August 2016

  12. Research article

    Chronic tarsal conjunctivitis

    Toxicity is rarely considered in the differential diagnosis of conjunctivitis, but we present here a new form of toxic conjunctivitis with unusual clinical features. Between 2010 and 2013, a new clinical prese...

    Nicholas Cook, Fizza Mushtaq, Christina Leitner, Andrew Ilchyshyn, George T. Smith and Ian A. Cree

    BMC Ophthalmology 2016 16:130

    Published on: 29 July 2016

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