Section edited by Hemant Khanna and Javier Zarranz-Ventura

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

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  1. Research article

    Association between polymorphism rs11200638 in the HTRA1 gene and the response to anti-VEGF treatment of exudative AMD: a meta-analysis

    Anti-angiogenesis treatments are the most commonly used treatments for the vision loss caused by exudative age-related macular degeneration (AMD), in which the anti-vascular endothelial growth factor (VEGF) dr...

    Ya-li Zhou, Chun-li Chen, Yi-xiao Wang, Yao Tong, Xiao-ling Fang, Lin Li and Zhao-yang Wang

    BMC Ophthalmology 2017 17:97

    Published on: 21 June 2017

  2. Research article

    Correlation of retinal nerve fibre layer and macular thickness with serum uric acid among type 2 diabetes mellitus

    Uric acid is a final breakdown product of purine catabolism in humans. It’s a potent antioxidant and can also act as a pro-oxidant that induces oxidative stress on the vascular endothelial cells, thus mediatin...

    Munisamy-Naidu Vinuthinee-Naidu, Embong Zunaina, Anuar Azreen-Redzal and Naing Nyi-Nyi

    BMC Ophthalmology 2017 17:91

    Published on: 14 June 2017

  3. Research article

    Correlation between short- and long-term effects of intravitreal ranibizumab therapy on macular edema after branch retinal vein occlusion: a prospective observational study

    The correlation between the short- and long-term effects of intravitreal ranibizumab (IVR) on macular edema after branch retinal vein occlusion (BRVO) remains unclear. We assessed the correlation between the s...

    Yoshiro Minami, Taiji Nagaoka, Akihiro Ishibazawa and Akitoshi Yoshida

    BMC Ophthalmology 2017 17:90

    Published on: 13 June 2017

  4. Research article

    Serum uric acid concentration is associated with hypertensive retinopathy in hypertensive chinese adults

    This cross sectional investigation included 12,966 subjects with hypertension, a cohort of the China Stroke Primary Prevention Trial (CSPPT), a randomized, multicenter clinical trial. This study aimed to explore ...

    Xuling Chen, Ying Meng, Jun Li, Hiacheng She, Liang Zhao, Jing Zhang, Yuan Peng, Kun Shang, Yadi Zhang, Xiaopeng Gu, Wenbin Yang, Yan Zhang, Jianping Li, Xianhui Qin, Binyan Wang, Xiping Xu…

    BMC Ophthalmology 2017 17:83

    Published on: 2 June 2017

  5. Research article

    Switch to aflibercept or ranibizumab after initial treatment with bevacizumab in eyes with neovascular AMD

    To evaluate changes in central macular thickness (CMT) and visual outcome in patients with neovascular age-related macular degeneration (AMD) treated initially with bevacizumab and subsequently switched to eit...

    Maria Waizel, Margarita G. Todorova, Michael Masyk, Katharina Wolf, Annekatrin Rickmann, Khaled Helaiwa, Björn R. Blanke and Peter Szurman

    BMC Ophthalmology 2017 17:79

    Published on: 23 May 2017

  6. Research article

    Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration

    To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photorec...

    Helena Giannakaki-Zimmermann, Giuseppe Querques, Inger Christine Munch, Daraius Shroff, David Sarraf, Xuejing Chen, Eduardo Cunha-Souza, Sarah Mrejen, Vittorio Capuano, Murilo W. Rodrigues, Charu Gupta, Andreas Ebneter, Martin S. Zinkernagel and Marion R. Munk

    BMC Ophthalmology 2017 17:67

    Published on: 15 May 2017

  7. Case report

    Case of asteroid hyalosis that developed severely reduced vision after cataract surgery

    To report our findings in a patient with asteroid hyalosis (AH) who had a severe reduction of his visual acuity following cataract surgery. The vision was improved by vitreous surgery.

    Ryosuke Ochi, Bumpei Sato, Seita Morishita, Yukihiro Imagawa, Masashi Mimura, Masanori Fukumoto, Takaki Sato, Takatoshi Kobayashi, Teruyo Kida and Tsunehiko Ikeda

    BMC Ophthalmology 2017 17:68

    Published on: 15 May 2017

  8. Research article

    24-month clinical outcomes of a treat-and-extend regimen with ranibizumab for wet age-related macular degeneration in a real life setting

    To evaluate the clinical effectiveness and analyze the outcomes of a treat-and-extend (T&E) treatment regimen with ranibizumab for wet age-related macular degeneration (ARMD) in real life clinical settings ove...

    Athanasios Vardarinos, Nitin Gupta, Raazia Janjua, Abigail Iron, Theo Empeslidis and Konstantinos T. Tsaousis

    BMC Ophthalmology 2017 17:58

    Published on: 27 April 2017

  9. Research article

    The influence of actin depolymerization induced by Cytochalasin D and mechanical stretch on interleukin-8 expression and JNK phosphorylation levels in human retinal pigment epithelial cells

    This study explores the role of actin cytoskeleton depolymerization induced by Cytochalasin D and mechanical stretch on the interleukin-8 (IL-8) expression and c-jun N-terminal kinase (JNK) phosphorylation lev...

    Meng Gao, Shen Wu, Jing Ji, JingXue Zhang, Qian Liu, YanKun Yue, Lu Liu, XinXin Liu and Wu Liu

    BMC Ophthalmology 2017 17:43

    Published on: 7 April 2017

  10. Case report

    Case report of an atypical early onset X-linked retinoschisis in monozygotic twins

    X-linked Retinoschisis (XLRS) is one of the most common macular degenerations in young males, with a worldwide prevalence ranging from 1:5000 to 1:20000. Clinical diagnosis of XLRS can be challenging due to th...

    Vittoria Murro, Roberto Caputo, Giacomo Maria Bacci, Andrea Sodi, Dario Pasquale Mucciolo, Sara Bargiacchi, Sabrina Rita Giglio, Gianni Virgili and Stanislao Rizzo

    BMC Ophthalmology 2017 17:19

    Published on: 24 February 2017

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