Section edited by Hemant Khanna and Javier Zarranz-Ventura

This section considers articles on all aspects of the prevention, diagnosis and management of retinal diseases as well as related molecular and cellular biology, genetics and pathophysiology. The section particularly welcomes prospective clinical studies, especially randomized controlled trials.

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  1. Case report

    Case report of an atypical early onset X-linked retinoschisis in monozygotic twins

    X-linked Retinoschisis (XLRS) is one of the most common macular degenerations in young males, with a worldwide prevalence ranging from 1:5000 to 1:20000. Clinical diagnosis of XLRS can be challenging due to th...

    Vittoria Murro, Roberto Caputo, Giacomo Maria Bacci, Andrea Sodi, Dario Pasquale Mucciolo, Sara Bargiacchi, Sabrina Rita Giglio, Gianni Virgili and Stanislao Rizzo

    BMC Ophthalmology 2017 17:19

    Published on: 24 February 2017

  2. Research article

    Demographics of patients receiving Intravitreal anti-VEGF treatment in real-world practice: healthcare research data versus randomized controlled trials

    While randomized controlled trials (RCTs) are based on strict inclusion/exclusion criteria, non-interventional studies (NISs) might provide additional information to guide management in patients more represent...

    F. Ziemssen, N. Feltgen, FG. Holz, R. Guthoff, A. Ringwald, T. Bertelmann, A. Wiedon and C. Korb

    BMC Ophthalmology 2017 17:7

    Published on: 19 January 2017

  3. Case report

    A retinopathy in young patient with co-inheritance of heterozygous alpha + −thalassemia and sickle trait: a case report

    The retinopathy is an uncommon complication in individuals with sickle cell trait except for the cases of sickle cell trait associated with systemic arterial hypertension, diabetes mellitus, syphilis, tubercul...

    Zohra Ouzzif, Aissam El Maataoui, Zeinab Traore, Asmae Biaz, Samira El Machtani, Abdellah Dami, Sanae Bouhsain, Nezha Messaoudi and Fatiha Benchrifa

    BMC Ophthalmology 2017 17:6

    Published on: 18 January 2017

  4. Research article

    Gestational diabetes mellitus and retinal microvasculature

    Small-vessel dysfunction may be an important consequence of chronic hyperglycemia. We examined the association between gestational diabetes mellitus (GDM), a state of transient hyperglycemia during pregnancy, ...

    Ling-Jun Li, Michael Kramer, Robyn J. Tapp, Ryan E. K. Man, Ngee Lek, Shirong Cai, Fabian Yap, Peter Gluckman, Kok Hian Tan, Yap Seng Chong, Jia Yu Koh, Seang Mei Saw, Yin Bun Cheung and Tien Yin Wong

    BMC Ophthalmology 2017 17:4

    Published on: 18 January 2017

  5. Research article

    Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies

    Colour Doppler analysis of ophthalmic vessels has been proposed as a promising tool in the diagnosis of various eye diseases, but the available diagnostic evidence has not yet been assessed systematically. We ...

    Mario Bittner, Livia Faes, Sophie C. Boehni, Lucas M. Bachmann, Reinier O. Schlingemann and Martin K. Schmid

    BMC Ophthalmology 2016 16:214

    Published on: 7 December 2016

  6. Research article

    Effect of bradykinin on TGF-β1-induced retinal pigment epithelial cell proliferation and extracellular matrix secretion

    To evaluate the effect of bradykinin (BK) on TGF-β1-induced retinal pigment epithelial (RPE) cell proliferation and extracellular matrix secretion and to elucidate the relationship between BK and the Erk/Akt s...

    Wenting Cai, Qingquan Wei, Qingyu Liu, Chengda Ren, Junling Liu, Ruiling Zhang, Mengmei He, Qianyi Wang, Yaru Du and Jing Yu

    BMC Ophthalmology 2016 16:199

    Published on: 10 November 2016

  7. Research article

    Retrospective, controlled observational case study of patients with central retinal vein occlusion and initially low visual acuity treated with an intravitreal dexamethasone implant

    Patients with initially low visual acuity were excluded from the therapy approval studies for retinal vein occlusion. But up to 28 % of patients presenting with central retinal vein occlusion have a baseline B...

    Sibylle Winterhalter, Gerrit Alexander vom Brocke, Daniel Pilger, Annabelle Eckert, Juliane Schlomberg, Anne Rübsam, Matthias Karl Klamann, Enken Gundlach, Tina Dietrich-Ntoukas and Antonia Maria Joussen

    BMC Ophthalmology 2016 16:187

    Published on: 27 October 2016

  8. Case report

    Preserved retinal sensitivity in spatial correspondence to an intrachoroidal cavitation area with full thickness retinal defect: a case report

    Intrachoroidal cavitation (ICC) in the temporal peripapillary area is a relatively frequent finding in high myopia. However, ICC associated with a full thickness retinal defect rarely observed. We report an un...

    Yoshiyuki Kita, Makoto Inoue, Gábor Hollό, Ritsuko Kita, Masahiko Sano and Akito Hirakata

    BMC Ophthalmology 2016 16:186

    Published on: 26 October 2016

  9. Case report

    Case report: Aqueous and Vitreous amino-acid concentrations in a patient with maple syrup urine disease operated on rhegmatogenous retinal detachment

    Maple syrup urine disease (MSUD) is a rare metabolic disorder, affecting the metabolism of branched chain amino-acids (Valine, Leukine, Isoleukine). We present a rare case of rhegmatogenous retinal detachment ...

    Menelaos G. Kanakis, Helen Michelakakis, Petros Petrou, Chrysanthi Koutsandrea and Ilias Georgalas

    BMC Ophthalmology 2016 16:170

    Published on: 3 October 2016

  10. Case report

    Atypical presentation of primary intraocular lymphoma

    In 2014, Pang et al. reported three cases with vitelliform submaculopathy as a preceding lesion of primary intraocular lymphoma (PIOL). Here, we report a case with an atypical presentation of PIOL who initiall...

    Koji Komatsu, Tsutomu Sakai, Toshikatsu Kaburaki, Hideki Tsuji and Hiroshi Tsuneoka

    BMC Ophthalmology 2016 16:171

    Published on: 3 October 2016

  11. Study protocol

    Nurse-administered intravitreal injections of anti-VEGF: study protocol for noninferiority randomized controlled trial of safety, cost and patient satisfaction

    Intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF) now improve or stabilize visual acuity in a number of previously untreatable eye diseases, of which the main are age-related...

    Dordi Austeng, Tora Sund Morken, Stine Bolme, Turid Follestad and Vidar Halsteinli

    BMC Ophthalmology 2016 16:169

    Published on: 1 October 2016

  12. Research article

    Systemic confounders affecting serum measurements of omega-3 and -6 polyunsaturated fatty acids in patients with retinal disease

    Omega-3 polyunsaturated fatty acids (PUFAs) have a highly anti-angiogenic effect in animal models. However, the clinical relevance of omega-3PUFAs in human retinal pathologies remains unclear. The ARED 2 study...

    Anima D. Bühler, Felicitas Bucher, Michael Augustynik, Jan Wöhrl, Gottfried Martin, Günther Schlunck, Hansjürgen Agostini, Daniel Böhringer, Gerhard Pütz and Andreas Stahl

    BMC Ophthalmology 2016 16:159

    Published on: 5 September 2016

  13. Research article

    Refractive shift of silicone oil tamponade in pseudophakic eye

    Refraction change of silicone oil (SO) tamponade in phakic and aphakic eye has been studied thoroughly; however, it is rarely studied in pseudophakic eye. In this paper we aimed to deduce a theoretical formula...

    Wei Fang, Jiuke Li, Xiaohong Jin, Jing Zhai, Yuanmin Dai and Yumin Li

    BMC Ophthalmology 2016 16:144

    Published on: 16 August 2016

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