Newly diagnosed exudative age-related macular degeneration treated with pegaptanib sodium monotherapy in US community-based practices: medical chart review study

Table 4 Mean (SD) change in best-corrected visual acuity (VA; logMAR*) from baseline by early disease definition.

	Met definition		Did not meet definition
Early disease definition	n	Mean change (SD)	n	Mean change (SD)	p-value
Definition No.1^†
Baseline to second treatment visit	18	0.04 (0.33)	41	-0.06 (0.21)	0.1702
Baseline to third treatment visit	18	0.08 (0.29)	41	-0.06 (0.20)	0.0283
Baseline to fourth treatment visit	18	0.12 (0.35)	41	-0.04 (0.26)	0.0597
Baseline to month 6 visit	18	0.16 (0.39)	41	0.03 (0.31)	0.1799
Definition No.2^‡
Baseline to second treatment visit	35	-0.06 (0.18)	31	0.03 (0.32)	0.1627
Baseline to third treatment visit	35	-0.09 (0.18)	31	0.03 (0.28)	0.0339
Baseline to fourth treatment visit	35	-0.08 (0.22)	31	0.09 (0.34)	0.0155
Baseline to month 6 visit	35	-0.05 (0.28)	31	0.13 (0.34)	0.0235

* Negative logMAR changes indicate improvement; positive logMAR changes indicate declination.
^†Early disease definition No.1: lesion size < 2 disk area, baseline VA study eye ≥ 20/80 Snellen, no scar or atrophy.
^‡Early disease definition No.2: occult and better VA at baseline in fellow eye (worse in study eye).
LogMAR = logarithm of the minimum angle of resolution; SD = standard deviation.

ISSN: 1471-2415