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Table 5 Baseline clinical characteristics of study eyes by early disease definition.

From: Newly diagnosed exudative age-related macular degeneration treated with pegaptanib sodium monotherapy in US community-based practices: medical chart review study

  Early disease definition No.1* Early disease definition No.2
Characteristic Met definition Did not meet definition p-value Met definition Did not meet definition p-value
Best-corrected VA (logMAR), mean (SD) 0.45 (0.10) 0.68 (0.27) 0.0010 0.62 (0.24) 0.64 (0.27) 0.7536
Time from NV-AMD diagnosis to baseline (months), mean (SD) 1.11 (3.12) 3.12 (6.94) 0.2456 2.49 (5.43) 0.90 (2.77) 0.1488
Angiographic subtype, n (%)    0.6817    < 0.0001
   Minimally classic 1 (5.6) 3 (7.3)   0 (0.0) 4 (12.9)  
   Occult 13 (72.2) 33 (80.5)   35 (100.0) 16 (51.6)  
   Predominantly classic 4 (22.2) 5 (12.2)   0 (0.0) 11 (35.5)  
   Missing 0 (0.0) 0 (0.0)   0 (0.0) 0 (0.0)  
Lesion location, n (%)    0.1345    1.0000
   Subfoveal 14 (77.8) 38 (92.7)   30 (85.7) 28 (90.3)  
   Extrafoveal 1 (5.6) 0 (0.0)   0 (0.0) 0 (0.0)  
   Juxtafoveal 2 (11.1) 3 (7.3)   3 (8.6) 2 (6.5)  
   Missing 1 (5.6) 0 (0.0)   2 (5.7) 1 (3.2)  
Pigment epithelial detachment, n (%)    0.5091    0.0202
   Present 5 (27.8) 8 (19.5)   11 (31.4) 2 (6.5)  
   Absent 13 (72.2) 33 (80.5)   19 (54.3) 26 (83.9)  
   Missing 0 (0.0) 0 (0.0)   5 (14.3) 3 (9.7)  
Cystoid macular oedema, n (%)    0.6639    0.0582
   Present 3 (16.7) 4 (9.8)   1 (2.9) 6 (19.4)  
   Absent 15 (83.3) 37 (90.2)   26 (74.3) 22 (71.0)  
   Missing 0 (0.0) 0 (0.0)   8 (22.9) 3 (9.7)  
Fibrosis, n (%)    1.0000    0.1585
   Present 0 (0.0) 2 (4.9)   1 (2.9) 2 (6.5)  
   Absent 18 (100.0) 39 (95.1)   26 (74.3) 27 (87.1)  
   Missing 0 (0.0) 0 (0.0)   8 (22.9) 2 (6.5)  
Geographic atrophy, n (%)    0.1637    0.2125
   Present 0 (0.0) 6 (14.6)   4 (11.4) 5 (16.1)  
   Absent 18 (100.0) 35 (85.4)   25 (71.4) 25 (80.6)  
   Missing 0 (0.0) 0 (0.0)   6 (17.1) 1 (3.2)  
Presence of blood, n (%)    0.5404    0.0806
   Yes 4 (22.2) 14 (34.1)   9 (25.7) 15 (48.4)  
   No 14 (77.8) 27 (65.9)   24 (68.6) 16 (51.6)  
   Missing 0 (0.0) 0 (0.0)   2 (5.7) 0 (0.0)  
  1. * Early disease definition No.1: lesion size < 2 disk area, baseline VA study eye ≥ 20/80 Snellen, no scar or atrophy within the lesion.
  2. Early disease definition No.2: occult and better VA at baseline in fellow eye (worse in study eye).
  3. LogMAR = logarithm of the minimum angle of resolution; NV-AMD = neovascular age-related macular degeneration; SD = standard deviation; VA = visual acuity.