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Table 5 Baseline clinical characteristics of study eyes by early disease definition.

From: Newly diagnosed exudative age-related macular degeneration treated with pegaptanib sodium monotherapy in US community-based practices: medical chart review study

 

Early disease definition No.1*

Early disease definition No.2

Characteristic

Met definition

Did not meet definition

p-value

Met definition

Did not meet definition

p-value

Best-corrected VA (logMAR), mean (SD)

0.45 (0.10)

0.68 (0.27)

0.0010

0.62 (0.24)

0.64 (0.27)

0.7536

Time from NV-AMD diagnosis to baseline (months), mean (SD)

1.11 (3.12)

3.12 (6.94)

0.2456

2.49 (5.43)

0.90 (2.77)

0.1488

Angiographic subtype, n (%)

  

0.6817

  

< 0.0001

   Minimally classic

1 (5.6)

3 (7.3)

 

0 (0.0)

4 (12.9)

 

   Occult

13 (72.2)

33 (80.5)

 

35 (100.0)

16 (51.6)

 

   Predominantly classic

4 (22.2)

5 (12.2)

 

0 (0.0)

11 (35.5)

 

   Missing

0 (0.0)

0 (0.0)

 

0 (0.0)

0 (0.0)

 

Lesion location, n (%)

  

0.1345

  

1.0000

   Subfoveal

14 (77.8)

38 (92.7)

 

30 (85.7)

28 (90.3)

 

   Extrafoveal

1 (5.6)

0 (0.0)

 

0 (0.0)

0 (0.0)

 

   Juxtafoveal

2 (11.1)

3 (7.3)

 

3 (8.6)

2 (6.5)

 

   Missing

1 (5.6)

0 (0.0)

 

2 (5.7)

1 (3.2)

 

Pigment epithelial detachment, n (%)

  

0.5091

  

0.0202

   Present

5 (27.8)

8 (19.5)

 

11 (31.4)

2 (6.5)

 

   Absent

13 (72.2)

33 (80.5)

 

19 (54.3)

26 (83.9)

 

   Missing

0 (0.0)

0 (0.0)

 

5 (14.3)

3 (9.7)

 

Cystoid macular oedema, n (%)

  

0.6639

  

0.0582

   Present

3 (16.7)

4 (9.8)

 

1 (2.9)

6 (19.4)

 

   Absent

15 (83.3)

37 (90.2)

 

26 (74.3)

22 (71.0)

 

   Missing

0 (0.0)

0 (0.0)

 

8 (22.9)

3 (9.7)

 

Fibrosis, n (%)

  

1.0000

  

0.1585

   Present

0 (0.0)

2 (4.9)

 

1 (2.9)

2 (6.5)

 

   Absent

18 (100.0)

39 (95.1)

 

26 (74.3)

27 (87.1)

 

   Missing

0 (0.0)

0 (0.0)

 

8 (22.9)

2 (6.5)

 

Geographic atrophy, n (%)

  

0.1637

  

0.2125

   Present

0 (0.0)

6 (14.6)

 

4 (11.4)

5 (16.1)

 

   Absent

18 (100.0)

35 (85.4)

 

25 (71.4)

25 (80.6)

 

   Missing

0 (0.0)

0 (0.0)

 

6 (17.1)

1 (3.2)

 

Presence of blood, n (%)

  

0.5404

  

0.0806

   Yes

4 (22.2)

14 (34.1)

 

9 (25.7)

15 (48.4)

 

   No

14 (77.8)

27 (65.9)

 

24 (68.6)

16 (51.6)

 

   Missing

0 (0.0)

0 (0.0)

 

2 (5.7)

0 (0.0)

 
  1. * Early disease definition No.1: lesion size < 2 disk area, baseline VA study eye ≥ 20/80 Snellen, no scar or atrophy within the lesion.
  2. Early disease definition No.2: occult and better VA at baseline in fellow eye (worse in study eye).
  3. LogMAR = logarithm of the minimum angle of resolution; NV-AMD = neovascular age-related macular degeneration; SD = standard deviation; VA = visual acuity.