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Table 6 Changes in progression measures by last visit* and month 24, n/N (%), PP population

From: Long-term effect of latanoprost/timolol fixed combination in patients with glaucoma or ocular hypertension: A prospective, observational, noninterventional study

Progression measure

Last visit

Month 24

Increase in horizontal or vertical cup/disc ratio by ≥0.2 (visit - baseline)

98/797 (12.3)

78/676 (11.5)

≥1 postbaseline optic disc hemorrhage

29/983 (3.0)

23/785 (2.9)

Decrease in ≥1 rim area, rim volume, and/or mean RNFL thickness by HRT (visit - baseline)

28/222 (12.6)

13/151 (8.6)

Visual field deterioration rated as progression by physician at ≥1 postbaseline visit

137/884 (15.5)

104/630 (16.5)

Increase in Aulhorn stage§ by ≥1 stage (visit - baseline)

64/370 (17.3)

43/258 (16.7)

Decrease in mean defect by ≥2.5 dB

59/371 (15.9)

45/285 (15.8)

  1. HRT = Heidelberg Retina Tomograph; PP = per protocol; RNFL = retinal nerve fiber layer.
  2. *Last visit = last postbaseline visit at which the parameter was recorded.
  3. To be included in the percentage, a subject must have had assessments at both the baseline and ≥1 postbaseline visit for the relevant measure.
  4. To be included in the percentage, a subject must have had ≥1 postbaseline assessment for the relevant measure.
  5. §Reflects all methods of determining Aulhorn stage.