Figure 1

Corneal ( A-D ) and conjunctival granuloma ( E-F ) caused by synthetic fibers from a toy teddy bear. A: A 4 × 5 mm oval corneal ulceration due to synthetic fibers in the 2-year-old girl (case 1). B-C: Haematoxylin-eosin (HE) staining of the inflamed corneal biopsy. The stroma contains multiple histiocytes and neutrophils and is embedded with bluish brown synthetic fibers (black arrows) exhibiting central black granular spots. Bars: 150 μm (B), 50 μm (C). D: Microscopy of synthetic fibers from the face of the 2-year-old girl's teddy bear causing the corneal ulceration. Bar: 50 μm. E-F: HE stained conjunctival biopsy from the 5-year-old girl (case 2) showing a normal differentiated epithelium (star = conjunctival surface). The connective tissue is infiltrated with inflammatory cells mostly eosinophils, and synthetic fibers (black arrows) surrounded by foreign body giant cell (white arrows). Bars: 200 μm (E), 50 μm (F).