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Table 4 Incidence of CVAs in subjects with DME and age/gender matched controls*, 1 July 2002 to 31 December 2005

From: Hospitalized cardiovascular events in patients with diabetic macular edema

   

DME Subjects

  

Diabetes Controls

Overall

n

Person-years

AMI events

rate/1000 PY

95% CI

n

Person-years

AMI events

rate/1000 PY

95% CI

All subjects

3519

4778.5

66

13.8

10.5 - 17.0

10557

13981.5

75

5.4

4.1 - 6.6

Females

1645

2220.9

38

17.1

11.7 - 22.5

4935

6502.4

38

5.8

4.0 - 7.7

Males

1874

2557.6

28

10.9

6.9 - 14.9

5622

7479.1

37

4.9

3.3 - 6.5

   

DME Subjects

  

Diabetes Controls

Age (years)

n

Person-years

AMI events

rate/1000 PY

95% CI

n

Person-years

AMI events

rate/1000 PY

95% CI

18-29

49

58.5

0

0.0

0.0 - 0.0

157

178.5

0

0.0

0.0 - 0.0

30-39

217

280.9

1

3.6

0.0 - 10.5

591

772.9

0

0.0

0.0 - 0.0

40-49

517

717.6

8

11.2

3.5 - 18.8

1522

1969.7

1

0.5

0.0 - 1.5

50-59

1144

1531.4

18

11.7

6.3 - 17.1

3271

4293.2

17

4.0

2.1 - 5.8

60-69

937

1245.5

21

16.7

9.6 - 23.8

2971

3777.9

18

4.7

2.6 - 6.9

70-79

516

745.0

14

18.8

9.1 - 28.5

1521

2229.4

20

9.0

5.1 - 12.9

80-89

139

199.6

4

19.6

0.7 - 38.6

524

759.9

19

25.1

14.0 - 36.3

  1. *Diabetes controls - diabetes subjects without ophthalmic manifestations, retinal disorders, or vitreous hemorrhage.
  2. DME = diabetic macular edema; CVA = cerebrovascular accident; PY = person-years; CI = confidence interval.