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Table 4 Incidence of CVAs in subjects with DME and age/gender matched controls*, 1 July 2002 to 31 December 2005

From: Hospitalized cardiovascular events in patients with diabetic macular edema

    DME Subjects    Diabetes Controls
Overall n Person-years AMI events rate/1000 PY 95% CI n Person-years AMI events rate/1000 PY 95% CI
All subjects 3519 4778.5 66 13.8 10.5 - 17.0 10557 13981.5 75 5.4 4.1 - 6.6
Females 1645 2220.9 38 17.1 11.7 - 22.5 4935 6502.4 38 5.8 4.0 - 7.7
Males 1874 2557.6 28 10.9 6.9 - 14.9 5622 7479.1 37 4.9 3.3 - 6.5
    DME Subjects    Diabetes Controls
Age (years) n Person-years AMI events rate/1000 PY 95% CI n Person-years AMI events rate/1000 PY 95% CI
18-29 49 58.5 0 0.0 0.0 - 0.0 157 178.5 0 0.0 0.0 - 0.0
30-39 217 280.9 1 3.6 0.0 - 10.5 591 772.9 0 0.0 0.0 - 0.0
40-49 517 717.6 8 11.2 3.5 - 18.8 1522 1969.7 1 0.5 0.0 - 1.5
50-59 1144 1531.4 18 11.7 6.3 - 17.1 3271 4293.2 17 4.0 2.1 - 5.8
60-69 937 1245.5 21 16.7 9.6 - 23.8 2971 3777.9 18 4.7 2.6 - 6.9
70-79 516 745.0 14 18.8 9.1 - 28.5 1521 2229.4 20 9.0 5.1 - 12.9
80-89 139 199.6 4 19.6 0.7 - 38.6 524 759.9 19 25.1 14.0 - 36.3
  1. *Diabetes controls - diabetes subjects without ophthalmic manifestations, retinal disorders, or vitreous hemorrhage.
  2. DME = diabetic macular edema; CVA = cerebrovascular accident; PY = person-years; CI = confidence interval.