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Table 5 Adjusted HRs for development of CVAs in subjects with DME compared with age/gender matched diabetes controls*, 1 July 2002 to 31 December 2005

From: Hospitalized cardiovascular events in patients with diabetic macular edema

Reference exposure

HR

95%

CI

p-value

DME versus diabetes controls

1.98

1.39 – 2.83

< 0.001

Covariates†

   

Angina

0.71

0.32 - 1.58

0.40

Cardiac arrhythmia

1.88

1.12 - 3.16

0.02

Charlson comorbidity index

1.13

1.02 - 1.24

0.02

Congestive heart failure

0.94

0.51 - 1.72

0.84

Heart disease

1.52

0.99 - 2.32

0.06

History of AMI

0.91

0.31 - 2.69

0.87

History of CVA

2.40

1.26 - 4.59

0.01

Hyperlipidemia

0.63

0.44 - 0.91

0.01

Hypertension

1.18

0.81 - 1.70

0.39

Other cerebrovascular disease

2.20

1.03 - 4.71

0.04

Prior anti-platelet or anticoagulant

1.07

0.62 - 1.83

0.81

  1. *Diabetes controls - diabetes subjects without ophthalmic manifestations, retinal disorders, or vitreous hemorrhage.
  2. † All covariates were included in the regression model; bolded text indicates statistical signficance.
  3. DME = diabetic macular edema; AMI = acute myocardial infarction; CVA = cerebrovascular accident; CI = confidence interval; HR = hazard ratios.