Figure 1
Graphic representation of the pupil response to blue light in one normal subject. The dotted line at the top is an extrapolation from baseline pupil size (BS) and corresponds to 1.0 on the Y-axis. Y-axis represents values of the normalized pupil size (NPS). Time −10 is the start of video recording of the pupil while in darkness. Time 0 is the onset of a 300 cd/m2 continuous blue light stimulus having duration of 20 seconds (vertical bars at the bottom). The arrow at point 1 shows where the maximal contraction occurs (the maximal CA). The arrow at point 2 is the 20th second of light stimulation and represents the sustained CA. The third parameter, 3, is the early poststimulus AUC (grey shaded area in the pupillogram) which is the summed pupil response during the first 10 s after light termination. The late poststimulus AUC, 4 (black shaded area), another summed post-illumination response parameter is taken from the 10th to 30th second after light termination. For definitions, see Methods.