Intrinsically photosensitive retinal ganglion cell function in relation to age: A pupillometric study in humans with special reference to the age-related optic properties of the lens

Table 3 Comparison of parameter change with age in a 30 year old subject versus a 60 year old subject

Parameter	Intensity cd/m²	30 yrs.	60 yrs.	%Change with age
Lens transmission		0.78	0.48↓	–38
Baseline pupil, mm		8.20	6.70↓	–18
Max. CA, %	300	53	56↑	4
Sust. CA, %	300	51	54↑	7
AUC early post.	300	2.6	3.1↑	17

CA, contraction amplitude; AUC, area under the curve.
Lens transmission. As age doubles, blue light transmission decreases by appr.40% and dark adapted baseline pupil diameter decreases by appr.20%. Pupil response parameters. An increased response was observed with increased age especially for early poststimulus AUC.
For abbreviations and definitions of parameters, see Table 1 and Methods.