Figure 1From: Increased expression of oxyproteins in the optic nerve head of an in vivo model of optic nerve ischemia Results of OxyBlot protein detection (A) and relative densitometric values of oxyprotein expression in the optic nerve head (B, C). Blotting was semi-quantified using densitometry. To compare the results of OxyBlot protein oxidation detection, relative densitometric values of treated groups were compared to control groups. Endothelin-1 (0.1 μg/day) was delivered to the perineural region of the anterior optic nerve by osmotically-driven minipumps for two (II), four (III), and eight weeks (IV). As a control, balanced salt solution was delivered for two (Ia) and eight weeks (Ib). There was a significant increase in the expression of oxyprotein after two weeks of endothelin-1 administration (p < 0.001, Mann Whitney U test). However, there was no difference between the two groups at eight weeks.Back to article page