Table 3 Pooled ORs and 95% CIs of the association between rs699947 polymorphism in the VEGFA gene and diabetic retinopathy
Contrasts | No. of studies (cases/controls) | Homogeneous co-dominant model | Heterogeneous co-dominant model | Dominant model | Recessive model | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AA vs. CC | AC vs. CC | AA + AC vs. CC | AA vs. AC + CC | ||||||||||||||
OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | ||
All | 8 (1204/1198) | 1.69 | 1.03-2.77 R | 66.3 | 0.004 | 1.27 | 0.96-1.69 R | 54.2 | 0.032 | 1.38 | 1.01-1.90 R | 67.1 | 0.003 | 1.49 | 0.99-2.24 R | 61.5 | 0.011 |
Ethnicity | |||||||||||||||||
European | 4 (470/431) | 1.79 | 0.87-3.67 R | 69.7 | 0.020 | 1.31 | 0.93-1.83 F | 0.0 | 0.565 | 1.47 | 1.07-2.02 F | 46.4 | 0.133 | 1.53 | 0.87-2.68 R | 68.6 | 0.023 |
East Asian | 4 (734/767) | 1.59 | 0.71-3.57 R | 71.7 | 0.014 | 1.26 | 0.79-2.02 R | 77.3 | 0.004 | 1.33 | 0.82-2.14 R | 80.3 | 0.002 | 1.46 | 0.72-2.96 R | 65.1 | 0.035 |