Table 4 Pooled ORs and 95% CIs of the association between rs2010963 polymorphism in the VEGFA gene and diabetic retinopathy
Contrasts | No. of studies (cases/controls) | Homogeneous co-dominant model | Heterogeneous co-dominant model | Dominant model | Recessive model | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CC vs. GG | CG vs. GG | CC + CG vs. GG | CC vs. CG + GG | ||||||||||||||
OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | OR | 95% CI | I 2(%) | P H | ||
All | 10 (1666/1782) | 1.11 | 0.80-1.56 R | 55.6 | 0.016 | 0.98 | 0.80-1.20 R | 40.6 | 0.087 | 1.01 | 0.81-1.26 R | 54.4 | 0.020 | 1.13 | 0.93-1.37 F | 28.1 | 0.186 |
Ethnicity | |||||||||||||||||
European | 5 (813/943) | 1.17 | 0.64-2.13 R | 70.0 | 0.010 | 0.90 | 0.66-1.23 R | 49.5 | 0.094 | 0.95 | 0.67-1.35 R | 65.0 | 0.022 | 1.25 | 0.81-1.92 R | 50.6 | 0.088 |
East Asian | 4 (733/760) | 1.06 | 0.67-1.69 R | 55.4 | 0.081 | 1.02 | 0.73-1.44 F | 50.3 | 0.110 | 1.04 | 0.72-1.49 R | 60.9 | 0.053 | 1.05 | 0.80-1.38 F | 17.1 | 0.306 |
South Asian | 1 (120/79) | 1.10 | 0.36-3.32 | - | - | 1.29 | 0.71-2.35 | - | - | 1.26 | 0.71-2.22 | - | - | 0.99 | 0.34-2.89 | - | - |
Type of DR | |||||||||||||||||
PDR | 7 (924/1376) | 1.14 | 0.71-1.83 R | 68.0 | 0.005 | 0.91 | 0.75-1.10 F | 34.2 | 0.167 | 0.97 | 0.73-1.28 R | 56.9 | 0.030 | 1.22 | 0.86-1.74 R | 53.5 | 0.045 |
NPDR | 3 (267/331) | 1.74 | 0.70-4.29 R | 62.9 | 0.067 | 1.45 | 0.73-2.87 R | 70.5 | 0.034 | 1.50 | 0.74-3.03 R | 74.5 | 0.020 | 1.36 | 0.85-2.18 F | 0.0 | 0.492 |