Figure 1

Schematic overview of LMD process. Sketch depicts the cap of the collection tube overlying the tissue of interest (orange) mounted on PEN membrane (transparent) coated over the glass slide (blue). Laser beam (red arrowhead) cuts through the PEN membrane and the tissue section. With RoboLPC function, the pulse of laser shot (outlined red arrow) hits the tissue section; and lifts the tissue from the slide surface. The microdissected tissue section is ejected into the collection cap along with the attached PEN membrane.