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Table 3 Levels of total free (proform/active), active matrix metalloproteinases and tissue inhibitor metalloproteinases in aqueous humor

From: Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance

  Control POAG PXS PXG
MMP2 7.13 ± 1.5 (5.3-10.2) 23.7 ±10.5 (7.16-44) (p < 0.001)* 15.8 ± 9.8 (6.1-29.3) (p < 0.001)* 23.4 ±17.3 (7.1-56.7) (p < 0.001)*
MMP3 3.11 ±0.8 (1.6-4.5) 7.5 ±15.8 (1.3-61) (p = 0.07) 6.8 ± 11.7 (1.3-44.,2) (p = 0.11) 9.8 ± 16.8 (1.5-72) (p < 0.001)*
MMP9 0.45 ± 0.25 (0.2-0.97) 0.7 ± 0.6 (0.2-2.1) (p = 0.08) 0.6 ± 0.33 (0.2-1.3) (p = 0.2) 0.6 ± 0.35 (0.17-1.5) (p = 0.2)
TIMP1 16.3 ± 6.1 (9.3-33.5) 33.6 ± 19.3 (11–75) (p < 0.001)* 31.2 ± 14.5 (12–58.5) (p < 0.001)* 37 ± 15 (15–60.3) (p < 0.001)*
TIMP2 3.7 ± 1.1 (2–5.7) 6.5 ± 3.1 ( 2.1-13.2) (p < 0.001)* 5.3 ± 2.1 (2.4-8.9) (p < 0.001)* 6.3 ± 3.1 (2.3-12.2) (p < 0.001)*
TIMP4 0.48 ± 0.25 (0.22-0.98) 0.95 ± 0.49 (0.24-1.76) (p < 0.001)* 0.48 ± 0.2 (0.13-0.76) (p = 0.93) 1.28 ± 1.38 (0.4-5.9) (p < 0.001)*
Active MMP2 0.21 ± 0.01 (0.2-0.24) 0.27 ± 0.06 (0.2-0.42) (p < 0.001)* 0.24 ± 0.03 (0.19-0.3) (p < 0.003)* 0.25 ± 0.04 (0.19-0.33) (p < 0.001)*
Active MMP3 0.29 ± 0.01 (0.26-0.3) 0.32 ± 0.02 (0.28-0.37) (p < 0.001)* 0.32 ± 0.01 (0.3-0.35) (p < 0.001)* 0.32 ± 0.2 (0.29-0.35) (p < 0.001)*
Act/tot. MMP2 0.008 ± 0,00086 0.006 ±0,00279 (p = 0.03) 0.005 ±0,00234 (p = 0.004)* 0.005 ± 0,00299 (p = 0.008)*
Act/tot. MMP3 0.008 ± 0,00183 0.008 ± 0,00061 (p = 0.93) 0.007 ± 0,0023 (p = 0.1) 0.008 ± 0,00072 (p = 0.93)
  1. MMP: Matrix metalloproteinase, TIMP: Tissue inhibitor metalloproteinase, POAG: Primary open angle glaucoma, PXS: Pseudoexfoliation, PXG: Pseudoexfoliation glaucoma. Concentrations (ng/mL) are presented as mean ± SD(range).
  2. p values refer to the Kruskal-Wallis multiple sample test for each study group versus controls. Statistical significance: p < 0.01 after Bonferroni correction.
  3. *: statistically significant.