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Table 4 MMP/TIMP ratios for the study and control groups

From: Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma, pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance

  CONTROL POAG PXS PXG
MMP2/TIMP1 0,464 ± 0,1 0,805 ± 0,31 (p > 0.1) 0,73 ± 0,753 (p > 0.1) 0,618 ± 0,360 (p > 0.1)
MMP2/TIMP2 2,07 ± 0,65 4,04 ± 2(p = 0.069) 2,8 ± 1,09 (p = 0.06) 4,34 ± 3,59 (p = 0.06)
MMP2/TIMP4 18,42 ±8,4 33,54 ± 25,61 (p = 0.031) 34,47 ± 19,07 (p < 0.001)* 28,36 ± 26,88 (p = 0.73)
MMP3/TIMP1 0.21 ± 0,085 0.17 ± 0.2 (p = 0.001)* 0.226 ± 0.4 (p < 0.001)* 0.26 ± 1.15 (p = 0.02)
MMP3/TIMP2 0.95 ± 0.48 0.88 ± 1.16 (p = 0.007)* 1.68 ± 3.17 (p = 0.01)* 2.07 ± 3.9 (p = 0.39)
MMP3/TIMP4 8,47 ± 4,86 11,93 ± 24,07 (p > 0.1) 14,16 ± 31,4 (p > 0.1) 16,85 ± 40,98 (p > 0.1)
MMP9/TIMP1 0.028 ± 0.014 0.023 ± 0.017 (p < 0.001)* 0.02 ± 0.019 (p < 0.001)* 0.02 ± 0.018 (p < 0.001)*
MMP9/TIMP2 0.13 ± 0.07 0.104 ± 0.059 (p < 0.001)* 0.12 ± 0.06 (p < 0.001)* 0.104 ± 0.063 (p < 0.001)*
MMP9/TIMP4 1.18 ± 0.99 1,12 ± 1.08 (p = 0.01)* 1.42 ± 0.7 (p = 0.4) 0.8 ± 0.59 (p < 0.001)*
  1. MMP: Matrix metalloproteinase, TIMP: Tissue inhibitor metalloproteinase, POAG: Primary open angle glaucoma, PXS: Pseudoexfoliation, PXG: Pseudoexfoliation glaucoma.
  2. Values are presented as mean ± SD.
  3. p values refer to the Mann Whitney test for each study group versus controls. Statistical significance: p < 0.01 after Bonferroni correction.
  4. *: statistically significant.