Figure 5
From: MAPK activation in mature cataract associated with Noonan syndrome
Western blot analysis of phosphorylated ERK. Phosphorylated extracellular signal-regulated kinase (p-ERK1/2) expression in Western blot. (A) A representative blot. p-ERK expression in lens lysates from the patient with Noonan syndrome and senile cataract (control). Western blot analysis revealed that p-ERK expression increased in lens lysates from the patient with Noonan syndrome. (B) Semi-quantitative analysis of the band intensity showed an increase in relative p-ERK expression (values normalized to total ERK expression) in lens lysates from the patient with Noonan syndrome compared with that from control (n = 6, *P < 0.001).