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Table 3 Utility estimates according to visual acuity in the better-seeing eye

From: Health state utilities in patients with diabetic retinopathy, diabetic macular oedema and age-related macular degeneration: a systematic review

Study reference HSUV instrument Mean utility (SD) Visual acuity
20/20 to 20/25 20/30 to 20/40 20/50 to 20/100 ≤ 20/200
Mean (SD) Mean (SD) Mean (SD) Mean (SD)
N N N N
Studies with visual acuity levels based on relevant conditions     
DR studies
Lloyd et al. [24] EQ-5D NR 0.75(0.23) 0.50(0.30) 0.68(0.29) 0.53(0.47)
68 13 10 7
       0.34(0.36)a
3
Lloyd et al. [24] HUI3 NR 0.78(0.22) 0.30(0.38) 0.61(0.35) 0.52(0.50)
68 13 10 7
       0.37(0.00)a
3
Brown et al. [16] TTO 0.79 0.86(0.17) 0.80(0.19) 0.77(0.18) 0.61(0.19)
(0.2) 72 130 95 36
Sharma et al. [27]   0.79 0.88(0.19) 0.79(0.22) 0.73(0.26) 0.73(0.22)
(0.2) NR NR NR NR
       0.48(0.47)a
NR
AMD studies
Aspinall et al. [19]c TTO 0.81 0.93 0.86 0.74 0.68
       0.76b
Brown et al. [16]   0.74(0.23) 0.84(0.21) 0.80(0.19) 0.71(0.22) 0.59(0.22)
  60 65 57 65
Lee et al. [23] SGd   0.89(0.23) 0.76(0.30) NR NR
23 21
Lee et al. [23] SGe   0.86(0.24) 0.39(0.37) NR NR
23 21
Studies with visual acuity levels not based on relevant conditions f     
Brown [30] TTO   0.89(0.17) 0.82(0.21) 0.74(0.21) 0.62(0.20)
82 98 89 38
       0.46 (0.29)a
18
Brown et al. [32]    0.88(0.15) 0.81(0.21) 0.72(0.21) 0.61(0.19)
127 218 83 72
Shah et al. [33]    0.88(0.19) 0.90(0.14) 0.76(0.23)  
71 43 22
Sharma et al. [34]    0.91(0.15) 0.80(0.21) 0.71(0.21) 0.62(0.20)
75 136 58 37
       0.473(0.32)
17a
Brown [30] SG   0.94 (0.12) 0.90(0.19) 0.81(0.21) 0.74(0.21)
82 98 89 38
       0.60(0.30)
18a
Sharma et al. [34]    0.95(0.11) 0.90(0.17) 0.77(0.28) 0.74(0.22)
75 136 58 37
       0.60(0.32)
17a
  1. Abbreviations: AMD age-related macular degeneration, DR diabetic retinopathy, EQ-5D EuroQol values, HUI3 Health utilities index Mark 3 values, NR not reported, SD standard deviation, SG standard gamble values, TTO time-trade-off estimates.
  2. aValues for levels corresponding to counting fingers to no light perception.
  3. bValues for levels corresponding to counting fingers to light perception.
  4. cVA level based on binocular distance vision and not VA in the better seeing-eye. Authors stated that the difference between the two measures was not significant. SD not calculated because of missing data. Figures shown were derived from the nearest equivalent Snellen categories of VA in the relevant article.
  5. dStandard gamble values based on the policy scale; anchors used were perfect vision/death.
  6. eStandard gamble values based on the vision scale; anchors used were perfect vision/unilateral blindness.
  7. fRelevant populations refers to patients with diabetic retinopathy and age-related macular degeneration. Macular oedema was not described in full, so it is unclear if patients had diabetic macular oedema.