Association of TLR7 and TSHR copy number variation with Graves’ disease and Graves’ ophthalmopathy in Chinese population in Taiwan

Table 1 The distribution of TSHR copy number variation in healthy control and patients with Graves’ disease and Graves’ ophthalmology

	Healthy control (N = 196)	GD (N = 481)	GO (N = 203)	GD versus Healthy control		GO versus Healthy control
CNV	N (%)	N (%)	N (%)	OR (95% CI)^b	OR (95% CI)^c	OR (95% CI)^b	OR (95% CI)^c
< 2	10 (5.1)	59 (12.3)	23 (11.3)	2.63(1.31-5.25)*	2.61 (1.29-5.28)*	2.35 (1.09-5.09)*	2.54 (1.15-5.61)*
2	178 (90.8)	400 (83.2)	174 (85.7)	1	1	1	1
>2	8 (4.1)	22 (4.6)	6 (3.0)	1.22 (0.54-2.80)	1.34 (0.55-3.27)	0.77 (0.26-2.26)	0.98 (0.32-3.01)
*P value* ^a		0.01*	*0.06*

GD, Graves’ disease. GO, Graves’ ophthalmology. CNV, copy number variance. N = number. OR, odds ratio. CI, confidence interval.
^a P value was calculated by Fisher’s exact test. Statistically significant results are indicated by asterisk (*).
^bUnivariate analyses. Statistically significant results are indicated by asterisk (*).
^cMutivariates analyses, adjusted for age and gender, interaction term (gender*TSHR) was not significant. Statistically significant results are indicated by asterisk (*).

ISSN: 1471-2415