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Table 2 The distribution of TLR7 copy number variation in healthy control and patients with Graves’ disease and Graves’ ophthalmology

From: Association of TLR7 and TSHR copy number variation with Graves’ disease and Graves’ ophthalmopathy in Chinese population in Taiwan

 

Healthy control (N = 196)

GD (N = 484)

GO (N = 203)

GD versus Healthy control

GO versus Healthy control

CNV

N (%)

N (%)

N (%)

OR (95% CI)c

OR (95% CI)d

OR (95% CI)c

OR (95% CI)d

CNV < normal CNV

7 (3.6)

6 (1.2)

1 (0.5)

0.34 (0.11-1.02)

0.24 (0.07-0.75)*

0.13(0.02-1.09)

0.13(0.02-1.05)

Normal CNV a

186 (94.9)

470 (97.1)

200 (98.5)

1

1

1

1

CNV > normal CNV

3 (1.5)

8 (1.7)

2 (1.0)

1.06 (0.28-4.02)

1.32 (0.33-5.26)

0.62 (0.10-3.75)

0.67 (0.11-4.15)

P value b

 

0.13

0.09

    
  1. GD, Graves’ disease. GO, Graves’ ophthalmology. CNV, copy number variation. N = number. OR, odds ratio. CI, confidence interval. #, number.
  2. aCNV = 1 for male or CNV = 2 for female.
  3. b P value was calculated by Fisher’s exact test.
  4. cUnivariate analyses. Statistically significant results are indicated by asterisk (*).
  5. dMutivariates analyses, adjusted for age and gender, interaction term (gender*TLR7) was not significant. Statistically significant results are indicated by asterisk (*).
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BMC Ophthalmology

ISSN: 1471-2415

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