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Figure 3 | BMC Ophthalmology

Figure 3

From: A hyporeflective space between hyperreflective materials in pigment epithelial detachment and Bruch’s membrane in neovascular age-related macular degeneration

Figure 3

Clinical course of the cleft in Case 10. Clinical courses of fundus and results of spectral-domain optical coherence tomography (SD-OCT) (vertical scans) in Case 10 at 3 months after first treatment (A,B), at 24 months (C,D) and at 25 months (E,F) after first treatment. A) A fundus photograph shows resolution of the intraretinal hemorrhage. B) SD-OCT shows absorption of the subretinal fluid (SRF) and cystoid macular edema (CME). C) At 24 months, recurrence of SRF and CME were present at the fovea. D) SD-OCT shows a hyporeflective space between the choroidal neovascularization (CNV) and Bruch’s membrane (cleft) (white arrows). Recurrent CME and SRF are also seen. Additional photodynamic therapy combined with intravitreal ranibizumab injections was performed. E, F) At 1 month after additional treatment, the hyporeflective space between the CNV and Bruch’s membrane has completely resolved. CNV beneath the retinal pigment epithelium is attached to Bruch’s membrane.

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