Table 2 Comparison of the mean intraocular pressure at each assessment visit in the per-protocol and intent-to-treat populations
Per-protocol population | ||||||||
|---|---|---|---|---|---|---|---|---|
Treatment group/time-point (baseline) | Mean IOP ± SD (mm Hg) | n | Treatment group/time-point (crossover) | Mean IOP ± SD (mm Hg) | n | |||
Baseline | Month 2 | Month 3 | Month 5 | Month 6 | ||||
Bim/tim 8 am | 19.5 ± 2.1 | 15.9 ± 3.6 | 14.6 ± 3.8 | 30 | Dorz/brim/tim 8 am | 16.6 ± 4.0 | 17.6 ± 3.4 | 30 |
Bim/tim 10 am | 18.3 ± 2.6 | 14.2 ± 3.1 | 13.6 ± 2.8 | Dorz/brim/tim 10 am | 13.3 ± 3.2 | 13.8 ± 3.1 | ||
Dorz/brim/tim 8 am | 20.2 ± 2.5 | 17.1 ± 3.4 | 16.9 ± 3.7 | 26 | Bim/tim 8 am | 17.0 ± 3.3 | 16.0 ± 2.9 | 26 |
Dorz/brim/tim 10 am | 19.4 ± 1.9 | 15.8 ± 2.9 | 15.7 ± 2.9 | Bim/tim 10 am | 16.0 ± 2.9 | 15.6 ± 2.3 | ||
Intent-to-treat population | ||||||||
Treatment group/time-point (baseline) | Baseline | Month 2 | Month 3 | n | Treatment group/time-point (crossover) | Month 5 | Month 6 | n |
Bim/tim 8 am | 19.5 ± 2.2 | 16.1 ± 3.4 | 14.8 ± 3.5 | 41 (BL)–35 (M3) | Dorz/brim/tim 8 am | 16.5 ± 3.8 | 17.7 ± 3.4 | 35 (M3)–26 (M6) |
Bim/tim 10 am | 18.1 ± 2.7 | 14.5 ± 2.3 | 13.7 ± 2.3 | Dorz/brim/tim 10 am | 13.3 ± 3.0 | 14.1 ± 3.3 | ||
Dorz/brim/tim 8 am | 19.8 ± 2.3 | 16.8 ± 3.7 | 16.7 ± 3.7 | 37 (BL)–28 (M3) | Bim/tim 8 am | 16.7 ± 3.3 | 16.6 ± 2.9 | 28 (M3)–32 (M6) |
Dorz/brim/tim 10 am | 18.6 ± 2.9 | 15.3 ± 2.6 | 15.6 ± 2.9 | Bim/tim 10 am | 15.7 ± 3.1 | 15.6 ± 2.3 | ||