Assessment of the effect of iris colour and having children on 5-year risk of death after diagnosis of uveal melanoma: a follow-up study

Table 2 Estimated hazard ratios of overall mortality and melanoma-specific mortality by patient characteristics

	Patients		Number of death	Overall mortality N = 95				Melanoma-specific mortality N = 79
	N	%	N	HR¹⁾	(95% CI)²⁾	HR³⁾	(95% CI)	HR¹⁾	(95% CI)	HR³⁾	(95% CI)
Gender
Men	216	47.1	60	1.0		1.0 ⁷⁾		1.0		1.0 ⁷⁾
Women	243	52.9	35	0.6	(0.4 - 0.9)	0.7	(0.4 - 1.0)	0.6	(0.4-1.0)	0.7	(0.4 - 1.1)
Largest basal tumour diameter (mm)
≤ 10	168	36.6	21	1.0		1.0 ⁸⁾		1.0		1.0 ⁸⁾
> 10 - ≤15	197	42.9	34	1.4	(0.8 - 2.5)	1.3	(0.8 - 2.3)	2.2	(1.1 - 4.3)	2.0	(1.0 - 4.0)
> 15	79	17.2	38	5.1	(3.0 - 8.8)	4.2	(2.4 - 7.4)	8.4	(4.2 – 16.1)	7.0	(3.5 - 13.9 )
Extra ocular growth
No	451	98.3		1.0		1.0 ⁸⁾		1.0		1.0 ⁸⁾
Yes	7	1.5	2	1.7	(0.4 - 7.0)	1.2	(0.3 - 4.8)	2.0	(0.5 - 8.2)	1.2	(0.3 - 4.8)
Ciliary body involvement
No	368	80.2	60	1.0		1.0 ⁹⁾		1.0		1.0 ⁹⁾
Yes	87	19.0	34	2.7	(1.8 - 4.2)	1.8	( 1.1 - 2.8)	3.0	(1.9 - 4.7)	1.7	(1.0 - 2.8)
Iris colour
Dark⁴⁾	62	13.5	7	1.0		1.0 ⁷⁾		1.0		1.0 ⁷⁾
Light⁵⁾	397	86.5	88	2.1	(1.0 - 4.5)	2.0	(0.9 - 4.3)	2.4	(1.0-6.0)	2.3	(0.9 - 5.8)
Children ⁶⁾
No	28	13.0	7	1.0		1.0 ¹⁰⁾		1.0		1.0 ¹⁰⁾
Yes	188	87.0	28	0.5	(0.2 - 1.2)	0.4	(0.2 - 1.0)	0.7	(0.3 - 1.7)	0.6	(0.2 - 1.7)
Number of children
0	28	12.9	7	1.0		1.0 ⁸⁾		1.0		1.0 ⁸⁾
1	62	28.7	10	0.6	(0.2 - 1.6)	0.5	(0.2 - 1.4)	0.8	(0.3 - 2.3)	0.7	(0.2 - 2.3)
2	87	40.3	12	0.5	(0.2 - 1.3)	0.4	(0.2 - 1.1)	0.5	(0.2 - 1.6)	0.5	(0.2 - 1.5)
≥3	39	18.1	6	0.6	(0.2 - 1.6)	0.4	(0.1 - 1.3)	0.8	(0.2 - 2.5)	0.7	(0.2 - 2.5)

¹⁾crude Hazard Ratio ²⁾95% Confidence Interval ³⁾adjusted Hazard Ratio.
⁴⁾brown, black iris colour ⁵⁾grey, blue, green, hazel iris colour.
⁶⁾only women.
⁷⁾adjusted for ciliary body involvement and largest basal tumour diameter ⁸⁾adjusted for ciliary body involvement ⁹⁾adjusted for largest basal tumour diameter ¹⁰⁾adjusted for age and graduation.

ISSN: 1471-2415