Hydrocortisone concentration influences time to clinically significant healing of acute inflammation of the ocular surface and adnexa – results from a double-blind randomized controlled trial

Table 3 Time (hours) to ≥50% reduction and to complete remission in CSS sum and subscores

Statistic	HC-ac 0.5% n = 133	HC-ac 1.0% n = 140	HC-ac 2.5% n = 138
Time to 50% reduction from baseline (days)
CSS total
Mean ± SD	112 ± 47	81 ± 36	81 ± 38
Median	112	68	74
Range	17 – 217	21 – 174	16 – 235
CSS objective signs
Mean ± SD	114 ± 51	83 ± 41	83 ± 39
Median	121	72	82
Range	15 – 272	18 – 238	16 – 183
CSS subjective symptoms
Mean ± SD	110 ± 48	82 ± 41	80 ± 42
Median	110	68	69
Range	17 – 224	18 – 253	14 – 266
Time to complete remission (days)
CSS Total = 0
Mean ± SD	250 ± 55	232 ± 45	228 ± 39
Median	240	220	220
Range	70 – 342	72 – 379	121 – 342
CSS objective signs subscore = 0
Mean ± SD	249 ± 56	232 ± 45	227 ± 40
Median	240	220	220
Range	70 – 342	72 – 379	121 – 342
CSS subjective symptoms subscore = 0
Mean ± SD	248 ± 586	224 ± 52	220 ± 48
Median	240	220	219
Range	70 – 342	72 – 379	70 – 342

CSS Clinical signs and symptoms n = number of subjects; SD standard deviation; range: minimum – maximum.

ISSN: 1471-2415