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Table 2 Genotype and allele distributions in AMD patients and control group

From: Associations of complement factor B and complement component 2 genotypes with subtypes of polypoidal choroidal vasculopathy

     Total
     Total AMD patients tAMD PCV RAP Control
     n % p-value n % p-value n % p-value n % p-value n %
rs547154 Genotype   G/G 601 88.8% 0.024 221 88.4% 0.192 335 89.1% 0.053 45 88.2% 0.561 229 83.6%
    T/G 74 10.9%   28 11.2%   40 10.6%   6 11.8%   41 15.0%
    T/T 2 0.3%   1 0.4%   1 0.3%   0 0.0%   4 1.5%
   Dominant model G/G 601 88.8% 0.032 221 88.4% 0.132 335 89.1% 0.046 45 88.2% 0.530 229 83.6%
    TG + TT 76 11.2%   29 11.6%   41 10.9%   6 11.8%   45 16.4%
   Recessive model TT 2 0.3% 0.061 1 0.4% 0.375 1 0.3% 0.168 0 0.0% 0.385 4 1.5%
  Allele   G 1276 94.2% 0.004* 470 94.0% 0.026 710 94.4% 0.005* 96 94.1% 0.260 499 91.1%
    T 78 5.8%   30 6.0%   42 5.6%   6 5.9%   49 8.9%
rs541862 Genotype   T/T 600 88.6% 0.054 221 88.4% 0.246 335 89.1% 0.078 44 86.3% 0.715 229 83.6%
    T/C 75 11.1%   28 11.2%   40 10.6%   7 13.7%   42 15.3%
    C/C 2 0.3%   1 0.4%   1 0.3%   0 00.0%   3 1.1%
   Dominant model T/T 600 88.6% 0.038 221 88.4% 0.132 335 89.1% 0.046 44 86.3% 0.835 229 83.6%
    TC + CC 77 11.4%   29 11.6%   41 10.9%   7 13.7%   45 16.4%
   Recessive model C/C 2 0.3% 0.147 1 0.4% 0.625 1 0.3% 0.315 00.0% 0.453 3 1.1%  
    TC + TT 675 99.7%   249 99.6%   375 99.7% 51   100.0%   271 98.9%
  Allele   T 1275 94.2% 0.025 470 94.0% 0.099 710 94.4% 0.027 95 93.1% 0.698 500 91.2%
    C 79 5.8%   30 6.0%   42 5.6%   7 6.9%   48 8.8%
rs2072633 rs2072633   G/G 115 17.0% 0.0024* 48 19.2% 0.120 61 16.2% 0.0026* 6 11.8% 0.048 69 25.2%
    G/A 323 47.7%   120 48.0%   178 47.3%   25 49.0%   134 48.9%
    A/A 239 35.3%   82 32.8%   137 36.4%   20 39.2%   71 25.9%
   Dominant model G/G 115 17.0% 0.0038* 48 19.2% 0.101 61 16.2% 0.0048* 6 11.8% 0.037 69 25.2%
    GA + AA 562 83.0%   202 80.8%   315 83.8%   45 88.2%   205 74.8%
   Recessive model A/A 239 35.3% 0.0051* 82 32.8% 0.083 137 36.4% 0.0045* 20 39.2% 0.052 71 25.9%
    GA + GG 438 64.7%   168 67.2%   239 63.6%   31 60.8%   203 74.1%
  Allele   G 553 40.8% 0.0005* 216 43.2% 0.037 300 39.9% 0.0005* 37 36.3% 0.013 272 49.6%
    A 801 59.2%   284 56.8%   452 60.1%   65 63.7%   276 50.4%
rs4151667 Genotype   T/T 653 96.5% 0.386 241 96.4% 0.514 363 96.5% 0.412 49 96.1% 0.797 261 95.3%
    A/T 24 3.5%   9 3.6%   13 3.5%   2 3.9%   13 4.7%
    A/A 0 0.0%   0 0.0%   0 0.0%   0 0.0%   0 0.0%
   Dominant mode T/T 653 96.5% 0.459 241 96.4% 0.664 363 96.5% 0.424 49 96.1% 0.797 261 95.3%
    AT + AA 24 3.5%   9 3.6%   13 3.5%   2 3.9%   13 4.7%
   Recessive model A/A 0 0.0% - 0 0.0% - 0 0.0% - 0 0.0% - 0 0.0%
    AT + TT 677 100.0%   250 100.0%   376 100.0%   51 100.0%   274 100.0%
  Allele   T 1330 98.2% 0.461 491 98.2% 0.667 739 98.3% 0.429 100 98.0% 0.779 535 97.6%
    A 24 1.8%   9 1.8%   13 1.7%   2 2.0%   13 2.4%
  1. AMD; age related macular degeneration tAMD; typical age related macular degeneration PCV; polypoidal choroidal vasculopathy RAP; retinal angiomatous proliferation.
  2. P- values are for the comparison between cases and controls.
  3. p- values for genotypes were calculated by Fisher’s exact test. (after Bonferroni correction *p < 0.0125).