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Table 1 Effects of Topical fluoroquinolones on Collagenase-type Metalloproteinases Immunohistochemical detection at 48 Hours

From: Effect of topical fluoroquinolones on the expression of matrix metalloproteinases in the cornea

Type of eye drops

 

MMP-1

MMP-8

Applied q.i.d.

Epithelium

  

Artificial Tear

Intact

0/14

0/14

 

Debrided

14/14

13/14

Ciloxan

Intact

14/14 **

13/14 **

 

Debrided

14/14

14/14

Ocuflox

Intact

13/14**

12/14**

 

Debrided

14/14

14/14

Quixin

Intact

13/14**

12/14**

 

Debrided

14/14

14/14

  1. Double masked observer determined the total positive immunostained eyes for MMP-1 and MMP-8 in each test group. Immunoreactivity is reported as number of positively immunostained corneas / total number of corneas examined. ** Statistically different when comparing the corresponding fluoroquinolone group to artificial tear. (P < 0.05 using Fisher's exact test analysis).