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Figure 4 | BMC Ophthalmology

Figure 4

From: Oxidative stress causes ERK phosphorylation and cell death in cultured retinal pigment epithelium: Prevention of cell death by AG126 and 15-deoxy-delta 12, 14-PGJ2

Figure 4

H2O2 induced nuclear condensation in ARPE-19 cells. ARPE-19 cells were treated with 1.5 mM H2O2 for various periods of time, and then processed for nuclear staining. Fig. 4A: untreated cells; Fig. 4B: 4-hour; Fig. 4C: 12-hour; Fig. 4D: 16-hour after treatment. Fig. 4E: Cells were pretreated with 1 μM 15d-PGJ2 overnight, followed by 1.5 mM H2O2 for 16 hours (without 15d-PGJ2). See text for detailed description of the results. Scale bar in Fig. 4E: 100 μm.

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