Primary graft failure associated with epithelial downgrowth: a case report

Aldave, Anthony J; Hollander, David A; Branco, Bruno; Crawford, Brooks; Abbott, Richard L

doi:10.1186/1471-2415-5-11

BMC Ophthalmology

Table 1 Summary of Reported Cases of Epithelial Downgrowth (ED) after Penetrating Keratoplasty (PK)

From: Primary graft failure associated with epithelial downgrowth: a case report

Author	Previous ocular surgery	PK Indication	Time from PK to ED diagnosis	Clinical features of ED	Diagnosis of ED	Final Anatomic/ Visual Status
Chiou et al [1]	3 PKs, 2 Trabs, 1 CPC	Graft Failure	13 months	Concentric peripheral retrocorneal membrane	Confocal microscopy	BSCVA 20/400
Feder & Krachmer [2]	ICCE	ABK	6 months	Iritis, glaucoma, posterior corneal line	Paracentesis, laser	Graft decompensation, glaucoma
	ICCE	PBK	7 months	Iritis, glaucoma	Paracentesis, laser	End-stage glaucoma
	ICCE	Fuchs' dystrophy	5 months	Posterior corneal line	Paracentesis, laser	Evisceration
	ECCE	KCN	13 years	Iritis	Paracentesis, laser	Phthisis bulbi
Mazow [7]	None	Endothelial dystrophy	5 months	Glaucoma	Histopathologic	Enucleation
Karabatsas [8]	2 PKs	PBK	8 months	Posterior corneal line, glaucoma	Clinical features	Not available
Sugar [3]	PK, ICCE	Graft failure	7 months	Retrocorneal membrane, pre-iris membrane	Histopathologic	Recurrent retrocorneal membrane; CF VA*
	ICCE	ABK;Fuchs' dystrophy	2 weeks	Descemet's deposits	Histopathologic	BSCVA 20/200^†
	LK, ICCE	Opacification of lamellar graft	16 months	Pre-iris membrane	Histopathologic	Scarred regraft; VA 10/400
	PK, ICCE	Graft failure	6 months	Retrocorneal membrane	Clinical features	Vascularized, edeamatous regraft, VA HM
Leibowitz [9]	2 PKs	Graft failure	1 month	Retrocorneal membrane; anterior chamber epithelial cyst	Histopathologic	Vascularized, opacified regraft
Groh & Naumann [10]	None	KCN	13 months	Anterior chamber epithelial cyst	Clinical features	VA 14/20
	None	Lattice corneal dystrophy	47 months	Anterior chamber epithelial cyst	Clinical features	VA 10/20
Wearne [11] ^‡	None	Scarring 2° to HSV keratitis	10 years	Anterior chamber epithelial cyst	Clinical features	VA 6/20
Yamaguchi et al. [12]	PK, ICCE	Graft failure	12 months	Retrocorneal membrane	Clinical features and histopathologic	Opacified regraft
Sidrys [13] ^¶	ICCE	PBK	3 weeks^§	Retrocorneal membrane	Clinical features and histopathologic	VA 6/60^Θ
Weiner [14]^#	Unknown	Various	Unknown	Retrocorneal membrane, glaucoma	Clinical features and histopathologic	Unknown
Kurz & D'Amico [16]	None	Corneal scar	10 months	None	Histopathologic	Unknown
	None	Corneal scar	8 weeks	None	Histopathologic	Enucleation**
Bennett & D'Amico [15]	None	KCN	3 years	Iris epithelial inclusion cyst	Clinical features and histopathologic	S/p sector iridectomy without recurrence
Claoue et al [17]	None	KCN	21 months	Iris epithelial inclusion cyst	Clinical features and histopathologic	S/p sector iridectomy without recurrence
Daneshvar et al. [6]	CE	ABK	1 year	Glaucoma, retrocorneal membrane	Laser, ultrasound biomicroscopy	No recurrence 16 months after repeat PK

BSCVA = best spectacle corrected visual acuity; ABK = aphakic bullous keratopathy; CF = counting fingers; CPC = cyclophotocoagulation; ECCE = extracapsular cataract extraction; HM = hand motions; HSV = herpes simplex virus; ICCE = intracapsular cataract extraction; KCN = keratoconus; LK = lamellar keratectomy; PBK = pseudophakic bullous keratopathy; Trab = trabeculectomy; * limited by ARMD; ^† h/o CME and RD s/p SB; ^‡same patient reported again in; 10^§ epithelial downgrowth through a cataract wound fistula; ^Θ limited by CME; ^¶ same patient reported again in; 12 ^# 13 patients reported; ** performed after traumatic wound dehiscence and total retinal detachment

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ISSN: 1471-2415

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