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Table 3 Influence of dorzolamide on retrobulbar hemodynamics. Ocular perfusion in the dorzolamide group. CDI measurements obtained from the patient group treated with dorzolamide (n = 12). The time period between between first and second measurement was 3–5 weeks. Data are given as mean ± standard deviation. Bold printed measures were subjected to statistical testing; all other parameters were observational only.

From: Effects of glaucoma drugs on ocular hemodynamics in normal tension glaucoma: a randomized trial comparing bimatoprost and latanoprost with dorzolamide [ISRCTN18873428]

   PSV (cms-1) EDV (cms-1) RI PI
OA before dorzolamide 29.6 ± 1.2 3.3 ± 0.4 0.89 ± 0.02 2.82 ± 0.25
  after dorzolamide 37.2 ± 3.5 4.4 ± 0.7 0.88 ± 0.02 2.64 ± 0.20
CRA before dorzolamide 7.3 ± 0.8 1.4 ± 0.1 0.80 ± 0.02 1.98 ± 0.18
  after dorzolamide 8.5 ± 0.8 1.8 ± 0.2 0.78 ± 0.02 1.97 ± 0.24
SPCA before dorzolamide 8.5 ± 0.8 1.9 ± 0.2 0.77 ± 0.02 1.79 ± 0.11
  after dorzolamide 12.8 ± 1.4 * 2.2 ± 0.2 0.80 ± 0.03 1.91 ± 0.13
LPCA before dorzolamide 10.9 ± 0.8 2.0 ± 0.3 0.73 ± 0.07 1.80 ± 0.22
  after dorzolamide 16.9 ± 1.7 2.9 ± 0.3 0.83 ± 0.01 1.95 ± 0.12
  1. Asterisk (*) denotes statistic significance (P < 0.006). Abbreviations: OA – Ophthalmic artery, CRA – central retinal artery, SPCA – short posterior ciliary artery, LPCA – long posterior ciliary artery, PSV – peak systolic velocity, EDV – enddiastolic velocity, RI – resistive index, PI – pulsatility index.