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Table 1 In VitroPlaque Assays. Human Adenovirus type 5 (Ad-5) viral titers [plaque forming units (pfu)/preliminary flask] in Virucidal, Antiviral and Viral Inactivation assays in HeLa (human cervical carcinoma), A549 (human cervical carcinoma) and SIRC (rabbit corneal) cells.

From: Efficacy of topical cobalt chelate CTC-96 against adenovirus in a cell culture model and against adenovirus keratoconjunctivitis in a rabbit model

Com-pound Cell Line Conc. Virucidal Antiviral Viral Inactivation
    Average   Standard Deviation Average   Standard Deviation Average   Standard Deviation
   (µg/ml) (PFU)   (PFU) (PFU)   (PFU) (PFU)   (PFU)
Negative Control (None) HeLa 0 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
  A549 0 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
  SIRC 0 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
CTC-96 HeLa (human cervix) 0 5.00 × 109 ± 0.00 × 100 4.00 × 1010 ± 0.00 × 100 5.33 × 109 ± 5.77 × 108
   5 4.67 × 109 ± 5.77 × 108 1.77 × 1010 ± 5.77 × 108 4.67 × 109 ± 5.77 × 108
   10 3.67 × 109 ± 5.77 × 108 1.33 × 1010 ± 5.77 × 108 2.47 × 109 ± 5.77 × 107
   25 3.67 × 109 ± 5.77 × 108 1.47 × 109 ± 5.77 × 107 1.17 × 109 ± 5.77 × 107
   50 6.67 × 101 ± 5.77 × 101 1.00 × 102 ± 1.00 × 102 3.33 × 101 ± 5.77 × 101
   100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
   250 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
  A549 (human lung) 0 3.07 × 109 ± 5.77 × 107 2.47 × 1010 ± 5.77 × 108 3.33E+09 ± 5.77 × 108
   5 2.77 × 109 ± 5.77 × 107 1.17 × 1010 ± 5.77 × 108 2.77E+09 ± 5.77 × 107
   10 2.27 × 109 ± 5.77 × 107 8.67 × 109 ± 5.77 × 108 1.47E+09 ± 5.77 × 107
   25 2.10 × 109 ± 0.00 × 100 9.33 × 107 ± 5.77 × 106 6.67E+08 ± 5.77 × 107
   50 6.67 × 101 ± 5.77 × 101 6.67 × 101 ± 5.77 × 101 3.33E+01 ± 5.77 × 101
   100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
   250 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
  SIRC (rabbit cornea) 0 5.67 × 108 ± 5.77 × 107 3.67 × 109 ± 5.77 × 108 5.33 × 108 ± 5.77 × 107
   5 4.67 × 108 ± 5.77 × 107 3.67 × 109 ± 5.77 × 108 3.00 × 108 ± 5.77 × 107
   10 4.33 × 108 ± 5.77 × 107 3.10 × 109 ± 1.00 × 108 3.33 × 108 ± 5.77 × 107
   25 5.77 × 107 ± 0.00 × 100 2.03 × 109 ± 5.77 × 107 1.00 × 107 ± 0.00 × 100
   50 3.33 × 101 ± 5.77 × 101 3.33 × 101 ± 5.77 × 101 0.00 × 100 ± 0.00 × 100
   100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100
   250 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100 0.00 × 100 ± 0.00 × 100