Table 1 In VitroPlaque Assays. Human Adenovirus type 5 (Ad-5) viral titers [plaque forming units (pfu)/preliminary flask] in Virucidal, Antiviral and Viral Inactivation assays in HeLa (human cervical carcinoma), A549 (human cervical carcinoma) and SIRC (rabbit corneal) cells.
Com-pound | Cell Line | Conc. | Virucidal | Antiviral | Viral Inactivation | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Â | Â | Â | Average | Â | Standard Deviation | Average | Â | Standard Deviation | Average | Â | Standard Deviation |
|  |  | (µg/ml) | (PFU) |  | (PFU) | (PFU) |  | (PFU) | (PFU) |  | (PFU) |
Negative Control (None) | HeLa | 0 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  | A549 | 0 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  | SIRC | 0 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
CTC-96 | HeLa (human cervix) | 0 | 5.00 × 109 | ± | 0.00 × 100 | 4.00 × 1010 | ± | 0.00 × 100 | 5.33 × 109 | ± | 5.77 × 108 |
|  |  | 5 | 4.67 × 109 | ± | 5.77 × 108 | 1.77 × 1010 | ± | 5.77 × 108 | 4.67 × 109 | ± | 5.77 × 108 |
|  |  | 10 | 3.67 × 109 | ± | 5.77 × 108 | 1.33 × 1010 | ± | 5.77 × 108 | 2.47 × 109 | ± | 5.77 × 107 |
|  |  | 25 | 3.67 × 109 | ± | 5.77 × 108 | 1.47 × 109 | ± | 5.77 × 107 | 1.17 × 109 | ± | 5.77 × 107 |
|  |  | 50 | 6.67 × 101 | ± | 5.77 × 101 | 1.00 × 102 | ± | 1.00 × 102 | 3.33 × 101 | ± | 5.77 × 101 |
|  |  | 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  |  | 250 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  | A549 (human lung) | 0 | 3.07 × 109 | ± | 5.77 × 107 | 2.47 × 1010 | ± | 5.77 × 108 | 3.33E+09 | ± | 5.77 × 108 |
|  |  | 5 | 2.77 × 109 | ± | 5.77 × 107 | 1.17 × 1010 | ± | 5.77 × 108 | 2.77E+09 | ± | 5.77 × 107 |
|  |  | 10 | 2.27 × 109 | ± | 5.77 × 107 | 8.67 × 109 | ± | 5.77 × 108 | 1.47E+09 | ± | 5.77 × 107 |
|  |  | 25 | 2.10 × 109 | ± | 0.00 × 100 | 9.33 × 107 | ± | 5.77 × 106 | 6.67E+08 | ± | 5.77 × 107 |
|  |  | 50 | 6.67 × 101 | ± | 5.77 × 101 | 6.67 × 101 | ± | 5.77 × 101 | 3.33E+01 | ± | 5.77 × 101 |
|  |  | 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  |  | 250 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  | SIRC (rabbit cornea) | 0 | 5.67 × 108 | ± | 5.77 × 107 | 3.67 × 109 | ± | 5.77 × 108 | 5.33 × 108 | ± | 5.77 × 107 |
|  |  | 5 | 4.67 × 108 | ± | 5.77 × 107 | 3.67 × 109 | ± | 5.77 × 108 | 3.00 × 108 | ± | 5.77 × 107 |
|  |  | 10 | 4.33 × 108 | ± | 5.77 × 107 | 3.10 × 109 | ± | 1.00 × 108 | 3.33 × 108 | ± | 5.77 × 107 |
|  |  | 25 | 5.77 × 107 | ± | 0.00 × 100 | 2.03 × 109 | ± | 5.77 × 107 | 1.00 × 107 | ± | 0.00 × 100 |
|  |  | 50 | 3.33 × 101 | ± | 5.77 × 101 | 3.33 × 101 | ± | 5.77 × 101 | 0.00 × 100 | ± | 0.00 × 100 |
|  |  | 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |
|  |  | 250 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 | 0.00 × 100 | ± | 0.00 × 100 |