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Table 2 Prediction of the average intraocular pressure in the initially treated eye (eye 1) following a uniocular trial by multivariable linear regression

From: Interpretation of uniocular and binocular trials of glaucoma medications: an observational case series

Cases (n, r2, Intercept).

IOP, eye 1

IOP, eye 2

 

Last baseline

During Trial

Change with trial.

 

Time A

Time B

Time B – Time A.

 

(b, p)

(b, p)

(b, p, p*)

All cases (168, 0.40, 6.9)

(0.27, <0.001)

(0.24, <0.001)

(0.04, 0.35, 0.34)

Baseline untreated (99, 0.44, 6.4)

(0.24, 0.002)

(0.34, <0.001)

(0.07, 0.43, 0.40)

Baseline treated (69, 0.36, 7.9)

(0.24, 0.002)

(0.20, 0.02)

(0.09, 0.10, 0.09)

Latanoprost (86, 0.44, 5.6)

(0.37, <0.001)

(0.20, 0.09)

(0.03, 0.79, 0.80)

Timolol only (33, 0.45, 8.2)

(0.22, 0.03)

(0.23, 0.06)

(0.05, 0.64, 0.70)

Brimonidine (17, 0.51, 3.5)

(0.29, 0.06)

(0.43, 0.10)

(-0.27, 0.20, 0.24)

Dorzolamide only (24, 0.61, 0.7)

(0.45, 0.004)

(0.48, 0.02)

(0.14, 0.04, 0.04)

  1. *p value for regression to predict square root of IOP, eye 1.