Table 4 Assessment of tolerability and performance

Tolerability – primary objectives

a. VAS tolerability questionnaire to evaluate:

   • Blurred vision

   • Ocular redness

   • Ocular burning

   • Ocular itching

b. Adverse events

Performance – secondary objectives

   • Clinical/symptomatologic evaluation (symptoms were evaluated using a VAS questionnaire recording: discomfort when blinking, burning, foreign body sensation, sensation of ocular fatigue/heaviness, sensation of tearing, desire to keep eyes closed, sensation of photophobia, sensation of blurred vision and sensation of pain)

   • Corneal and conjunctival staining

   • Intraocular pressure (IOP)

   • Tear film break-up time (BUT)

   • Number of daily instillations