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Table 3 Statistical analysis of 18S rRNA PCR diagnostic evaluation

From: Specific detection of fungal pathogens by 18S rRNA gene PCR in microbial keratitis

18S rRNA PCR assay

Microscopy and Culture

Total

 

Positive

Negative

 

Positive

10

1

11

Negative

1

18

19

Total

11

19

30

  1. a. True positive = 10, false positive = 1, false negative = 1, true negative = 18.
  2. b. This leads to estimates of sensitivity = 0.91 (95% CI = 0.59 to 1.00), specificity = 0.95 (95% CI = 0.74 to 1.00) and a diagnostic odds ratio (DOR) of 180 (7.8 to 8195.8).
  3. c. The positive likelihood ratio (LR+) is 17.3 (95% CI = 2.5 to 117.4) and the negative likelihood ratio (LR-) is 0.10 (95% CI = 0.03 to 0.36).