Morphological alterations in lenses from older wild type and R49C
neo knock-in mice. (A) Lens from wild type 10-month-old mouse with normal fiber cells near the lens surface and normal appearing fibers. (B) Large swollen cells and gaps between fiber cells in lens from 10-month-old R49Cneo/R49Cneo mouse. (C) The swollen fiber cells increased in both size and number with increased age, and extended towards the center of the lens. The number of swollen cells per lens section is shown.