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Table 2 TBUT at baseline and days 7 and 30 after cataract surgery

From: Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study

TBUT in patient subgroups Treatment group Control group P value*
n Score n Score
All patients, seconds (mean ± SD)
  Baseline 90 7.7 ± 4.8 90 7.2 ± 4.1 0.7583
  At day 7 85 8.5 ± 5.5 85 6.6 ± 3.8 0.0475
  At day 30 83 9.0 ± 5.9 82 6.7 ± 4.8 0.0258
  Change from baseline at day 7 85 0.9 ± 4.9 85 −0.5 ± 3.4** 0.0171
  Change from baseline at day 30 83 1.3 ± 5.6** 82 −0.4 ± 4.4** 0.0093
Dry eye prior to surgery subgroup, s (mean ± SD)
  Baseline 35 3.5 ± 1.2 33 3.8 ± 1.0 0.2912
  At day 7 33 5.4 ± 3.8 32 4.5 ± 2.4 0.5064
  At day 30 32 5.7 ± 4.2 31 4.1 ± 2.0 0.3146
  Change from baseline at day 7 33 2.0 ± 3.6*** 32 0.7 ± 2.2 0.0805
  Change from baseline at day 30 32 2.3 ± 3.8*** 31 0.3 ± 2.0 0.0365
Non-dry eye prior to surgery subgroup, s (mean ± SD)
  Baseline 55 10.3 ± 4.4 57 9.2 ± 4.0 0.1283
  At day 7 52 10.5 ± 5.6 53 7.8 ± 4.0 0.0168
  At day 30 51 11.0 ± 6.0 51 8.3 ± 5.4 0.0164
  Change from baseline at day 7 52 0.1 ± 5.5 53 −1.3 ± 3.8** 0.1300
  Change from baseline at day 30 51 0.7 ± 6.4 51 −0.9 ± 5.3** 0.1501
  1. TBUT, tear breakup time; SD, standard deviation.
  2. *P values for the difference between groups calculated using Wilcoxon rank sum test.
  3. **P ≤ 0.0349; ***P ≤ 0.0007 for change from baseline calculated using Wilcoxon signed rank test.
  4. Significant differences between treatment groups and significant changes from baseline are indicated in bold font.