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Table 3 Sensitivity analysis of significantly associated variants

From: Common synonymous variants in ABCA4 are protective for chloroquine induced maculopathy (toxic maculopathy)

 

Cases vs. Controls

Cases vs. EUR †

Variant

OR (95% CI # ), unadjusted model

OR (95% CI # ), adjusted model*

OR (95% CI # ), unadjusted model

c.5682G > C

0.30 (0.09-0.85)

0.05 (0.00 - 1.00)

0.43 (0.16-0.94)

c.5814A > G

0.16 (0.03-0.63)

0.01 (0.00 - 0.27)

0.32 (0.08-0.91)

c.5844A > G

0.16 (0.03-0.63)

0.01 (0.00 - 0.27)

0.29 (0.07-0.80)

  1. *Adjusted jointly for age, gender, treatment duration and daily dose per ideal bodyweight.
  2. †Patients treated with CQ and affected with toxic maculopathy were compared to data from 267 European individuals obtained from the 1000 Genomes Project.
  3. #Confidence intervals.
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BMC Ophthalmology

ISSN: 1471-2415

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