Figure 3

Direct comparison of IVT-AFL 2q8 (plus sham laser) or IVR 0.5 mg PRN (plus sham laser) versus laser (plus sham injection) for mean BCVA change from baseline in key studies. Indirect comparison (IVT-AFL 2q8 vs IVR 0.5 mg PRN) (Bucher analysis) also shown. BCVA, best-corrected visual acuity; CI, confidence interval; IVR, intravitreal ranibizumab; IVT-AFL, intravitreal aflibercept; PRN, as-needed; VEGF, vascular endothelial growth factor.