Systematic review and mixed treatment comparison of intravitreal aflibercept with other therapies for diabetic macular edema (DME)

Table 4 Indirect comparison (Bucher analysis) of the effects of IVT-AFL 2q8 versus dexamethasone 0.7 mg implants on 12-month visual outcomes

Outcome	Studies (n)	FE: effect size [95% CI]	RE: effect size [95% CI]
Gain ≥ 10 ETDRS letters	3 studies (n = 1123)*	RR = 2.10 [1.29–3.40]	RR = 2.10 [1.21–3.66]
Gain ≥ 10 ETDRS letters	3 studies (n = 1123)*	OR = 3.51 [1.79–6.88]	OR = 3.52 [1.60–7.72]

*VIVID-DME, VISTA-DME, and PLACID [13,36].
CI, confidence interval; ETDRS, Early Treatment Diabetic Retinopathy Study; FE, fixed effects; IVT-AFL, intravitreal aflibercept; OR, odds ratio; RE, random effects; RR, relative risk/risk ratio.

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