Effectiveness and relevant factors of 2 % rebamipide ophthalmic suspension treatment in dry eye

Ueda, Kaori; Matsumiya, Wataru; Otsuka, Keiko; Maeda, Yoshifumi; Nagai, Takayuki; Nakamura, Makoto

doi:10.1186/s12886-015-0040-0

BMC Ophthalmology

Table 4 Independent variables for the changes of dry eye related symptom scores and fluorescein ocular surface staining score from baseline to 12 weeks

From: Effectiveness and relevant factors of 2 % rebamipide ophthalmic suspension treatment in dry eye

a) Independent variables for the changes of dry eye related symptom scores
	The changes of dry eye related symptom scores from baseline to 12 weeks
	Crude			Multivariate
	Unstandardized regression coefficient	Correlation coefficient(r)	P value	Unstandardized regression coefficient	Correlation coefficient(r)	P value
Age	−0.06	−0.092	0.67
Gender (male)	4.71	0.24	0.25
Sjogren syndrome	−1.37	−0.097	0.65
The presence of previous treatment	−5.71	−0.45	0.029
Dry eye symptom score	−0.44	−0.47	0.021
Schirmer’s test	0.048	0.39	0.30
Fluorescein ocular surface staining score	−1.26	−0.45	0.028
Fluorescein corneal staining score	−1.81	−0.12	0.25
Fluorescein conjunctiva staining score	−1.81	−0.48	0.017	−1.81	−0.48	0.017*
TBUT	−0.7955	−0.1192	0.5791
The presence of auto-immune disease	−0.589	−0.045	0.83
b) Independent variables for the changes of fluorescein ocular surface staining score
	The changes of fluorescein ocular surface staining score from baseline to 12 weeks
	Crude			Multivariate
	Unstandardized regression coefficient	Correlation coefficient(r)	P value	Unstandardized regression coefficient	Correlation coefficient(r)	P value
Age	−0.019	−0.14	0.51
gender (male)	−0.38	−0.095	0.66
Sjogren syndrome	−0.20	−0.069	0.75
The presence of previous treatment	−0.84	−0.32	0.13
Dry eye symptom score	−0.10	−0.52	0.0097	−0.10	−0.52	0.0097*
Schirmer’s test	0.048	0.22	0.32
Fluorescein ocular surface staining score	−0.22	−0.38	0.070
Fluorescein corneal staining score	−0.39	−0.25	0.23
Fluorescein conjunctiva staining score	−0.29	−0.37	0.076
TBUT	−0.036	−0.029	0.89
The presence of auto-immune disease	0.17	0.064	0.77

*The significant independent variable in the multiple regression analysis

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