Table 2 Results of meta-analysis for TCF4 polymorphisms and risk of FED
From: Association of TCF4 polymorphisms and fuchs’ endothelial dystrophy: a meta-analysis
Polymorphism (comparison) | No. of studies | OR (95%CI) | P | Heterogeneity | P Egger’s testa | P Begg’s testb | ||
|---|---|---|---|---|---|---|---|---|
x 2 | I2 | P | ||||||
rs613872 | ||||||||
G vs. T | 10 | 4.19(3.53–4.97) | <0.001 | 16.60 | 45.8 % | 0.055 | 0.411 | 0.474 |
GG vs. GT/TT | 6 | 4.27(2.54–7.19) | <0.001 | 6.20 | 19.3 % | 0.288 | 0.295 | 0.260 |
GG/GT vs. TT | 7 | 6.29(4.23–8.93) | <0.001 | 16.23 | 63.0 % | 0.013 | 0.586 | 0.707 |
GG VS. TT | 6 | 10.64(5.28–21.41) | <0.001 | 9.43 | 47.0 % | 0.093 | 0.378 | 0.452 |
GT VS. TT | 6 | 6.08 (4.28–8.64) | <0.001 | 12.72 | 60.7 % | 0.026 | 0.938 | 0.707 |
rs2286812 | ||||||||
T vs C | 5 | 1.77(1.19–2.63) | 0.005 | 12.10 | 66.9 % | 0.017 | 0.207 | 0.180 |
rs17595731 | ||||||||
C vs G | 3 | 4.70(3.06–7.21) | <0.001 | 1.27 | 0.0 % | 0.530 | 0.775 | 1.000 |
rs9954153 | ||||||||
G vs T | 3 | 2.43(1.97–3.01) | <0.001 | 0.20 | 0.0 % | 0.906 | 0.793 | 1.000 |