Fig. 1

External eye photos and hematoxylin-eosin staining of sebaceous cell carcinoma (SeCC) of eyelids. a-d: Preoperative photos show (a) A fleshy mass arising from the lower eyelid tarsus (Case 2), (b) A small ulcerated nodule at the right upper eyelid (Case 6), (c) An ill-defined lesion involving the upper eyelid, masquerading as blepharitis (Case 12), (d) An advanced tumor diffusely infiltrative growth that involves the whole upper tarsus (Case 16). e-h: The corresponding scanning views (4×) of hematoxylin-eosin sections of the eyelid-conjunctiva specimens labled as A-D in the upper row. i-l: Higher power magnification of scanning views in the middle row shows (i) solid sheets of pleomorphic carcinoma cells without apparent sebaceous differentiation (×20), (j) irregular and interconnecting nests of carcinoma cells with foamy cytoplasmic droplets indicative of sebaceous differentiation (×40), (k) intraepithelial (pagetoid) growth of sebaceous carcinoma cells involving the epidermis (×20), (l) a comedo pattern of sebaceous carcinoma showing central necrosis (×20)