Table 3 Pooled ORs and 95 % CIs of the association between the VEGF rs2146323 polymorphism and DR in six models
Model | Contrasts | Number of study | Pooled method | OR (95 % CI) | Z | Pz | Heterogeneity | |
|---|---|---|---|---|---|---|---|---|
I2 | P | |||||||
Dominant CA + AA vs. CC | Chinese | 1 | Fixed-effect | 1.40 (0.97–2.00) | 1.81 | 0.070 | ||
Caucasian | 3 | 1.37 (1.03–1.81) | 2.16 | 0.031 | 0.0 % | 0.538 | ||
Overall | 4 | 1.38 (1.10–1.72) | 2.82 | 0.005 | 0.0 % | 0.741 | ||
Allele A vs. C | Chinese | 1 | Random-effect | 1.52 (1.14–2.03) | 2.88 | 0.004 | ||
Caucasian | 3 | 1.03 (0.75–1.43) | 0.19 | 0.847 | 52.1 % | 0.124 | ||
Overall | 4 | 1.16 (0.88–1.53) | 1.02 | 0.306 | 59.9 % | 0.058 | ||
Recessive AA vs. CA + CC | Chinese | 1 | Random-effect | 2.65 (1.40–5.00) | 3.01 | 0.003 | ||
Caucasian | 3 | 0.73 (0.29–1.85) | 0.67 | 0.504 | 63.9 % | 0.063 | ||
Overall | 4 | 1.04 (0.43–2.53) | 0.09 | 0.928 | 77.5 % | 0.004 | ||
Co-dominant CA vs. CC | Chinese | 1 | Fixed-effect | 1.15 (0.78–1.71) | 0.72 | 0.470 | ||
Caucasian | 3 | 1.52 (1.13–2.04) | 2.75 | 0.006 | 0.0 % | 0.601 | ||
Overall | 4 | 1.37 (1.08–1.74) | 2.63 | 0.008 | 0.0 % | 0.529 | ||
Co-dominant AA vs. CC | Chinese | 1 | Random-effect | 2.80 (1.46–5.37) | 3.09 | 0.002 | ||
Caucasian | 3 | 0.89 (0.35–2.24) | 0.25 | 0.801 | 59.0 % | 0.087 | ||
Overall | 4 | 1.26 (0.56–2.84) | 0.55 | 0.585 | 70.8 % | 0.016 | ||
Over-dominant CA vs. CC + AA | Chinese | 1 | Random-effect | 1.00 (0.68–1.46) | 0.01 | 0.991 | ||
Caucasian | 3 | 1.55 (1.09–2.21) | 2.41 | 0.016 | 29.1 % | 0.244 | ||
Overall | 4 | 1.36 (0.96–1.91) | 1.74 | 0.081 | 51.2 % | 0.105 | ||
Additive CC vs. AA | Chinese | 1 | Random-effect | 0.36 (0.19–0.69) | 3.09 | 0.002 | ||
Caucasian | 3 | 1.10 (0.46–2.66) | 0.22 | 0.828 | 55.2 % | 0.107 | ||
Overall | 4 | 0.79 (0.36–1.76) | 0.57 | 0.567 | 69.8 % | 0.019 | ||