Table 3 Genes down-regulated in endothelium of mice dysfunctional corneal allografts relative to syngenic control as detected by PCR array

Antioxidant

Glutathione Peroxidases (Gpx)

 Glutathione peroxidase 5

Gpx5

−3.18

0.1479

 Glutathione peroxidase 6

Gpx6

−3.05

0.0021

 Glutathione peroxidase 7

Gpx7

−4.48

0.0017

Peroxiredoxins (TPx)

 Peroxiredoxin 4

Prdx4

−1.22

0.0478

Other Peroxidases

 Lactoperoxidase

Lpo

−4.32

0.0007

 Prostaglandin-endoperoxide synthase 2

Ptgs2

−1.43

0.0011

 Recombination activating gene 2

Rag2

−3.00

0.0058

 Thyroid peroxidase

Tpo

−2.64

0.0016

Other Antioxidants

 Nucleoredoxin

Nxn

−1.19

0.0105

ROS Metabolism

Superoxide Metabolism

 Cytochrome b-245, alpha polypeptide

Cyba

−1.43

0.0122

 Neutrophil cytosolic factor 2

Ncf2

−1.87

0.0045

 NADPH oxidase 1

Nox1

−4.14

0.0052

 NADPH oxidase 4

Nox4

−1.58

0.022

 NADPH oxidase activator 1

Noxa1

−3.11

0.1457

 NADPH oxidase organizer 1

Noxo1

−1.63

0.0349

 RecQ protein-like 4

Recq14

−1.83

0.0016

Other genes involved in ROS Metabolism

 Interleukin 19

Il19

−3.37

0.0001

 Interleukin 22

Il22

−3.41

0.0008

Oxidative stress responsive genes

 Dual oxidase 1

Duox1

−2.65

1.80E-05

 Eosinophil peroxidase

Epx

−4.46

2.00E-04

 Myeloperoxidase

Mpo

−3.49

0.0041

 Membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)

Mpp4

−3.11

0.0043

 Nudix (nucleoside diphosphate linked moiety X)-type motif 15

Nudt15

−1.18

0.0106

 Uncoupling protein 3 (mitochondrial, proton carrier)

Ucp3

−1.58

0.0088

Oxygen transporters

 Hemoglobin, theta 1A

Hbq1a

−3.13

0.0511

 Myoglobin

Mb

−3.44

0.0604

 Xin actin-binding repeat containing 1

Xirp1

−3.13

0.0003