Fig. 2

Ophthalmologic examination images before and 6 months after anti-VEGF therapy for central retinal vein occlusion. Fundus photograph, spectral-domain optical coherence tomographic (SD-OCT) images, laser speckle flowgraphic (LSFG) images, and microperimetric maps before and 6 months after an initial anti-VEGF therapy of the right eye of a 66-year-old man with cystoid macular edema (CME) due to a central retinal vein occlusion are presented. The decimal best-corrected visual acuity was 0.3 before the treatment and 0.1 at 6 months after the treatment. a: Fundus photograph at the baseline. Note that the venous tortuosity is larger as compared with fundus photograph presented in Fig. 1a. b: SD-OCT image at the baseline shows CME. c: SD-OCT image at 6 months indicates residual CME and retinal thinning around the fovea. d: A false-color composite map at the optic nerve head was created using LSFG at the baseline. The red area indicates a faster blood flow, and the blue area indicates a slower blood flow. e: A false-color composite map by LSFG at 6 months. Note the decrease of blood flow as compared with the LSFG map before the treatment (d). f: Microperimetric map at the baseline. The mean retinal sensitivity at the 37 locations is 14.4 dB. g: Microperimetric map image at 6 months. The mean retinal sensitivity at the 37 locations is 10.6 dB