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Table 1 Comparison of four fluorophotometry scoring schemes with other dry eye diagnostic tests

From: Corneal permeability changes in dry eye disease: an observational study

  

OSDI

OSDI Quartiles

TBUT

Fluorescein

Lissamine

Aggregate score

DIFF5

Correlation Coefficient

.172

.056

.213

−.086

−.075

.030

Significance

.444

.805

.340

.703

.739

.895

DIFF10

Correlation Coefficient

.118

−.030

.050

−.163

−.274

−.186

Significance

.602

.895

.826

.468

.216

.408

DIFF15

Correlation Coefficient

.093

−.046

−.031

−.174

−.357

−.259

Significance

.681

.837

.891

.439

.102

.245

DIFF30

Correlation Coefficient

.276

.256

−.118

−.037

.163

−.028

Significance

.213

.250

.602

.870

.469

.903

LOGDIFF5

Correlation Coefficient

.172

.056

.213

−.086

−.075

.030

Significance

.444

.805

.340

.703

.739

.895

LOGDIFF10

Correlation Coefficient

−.013

−.137

−.028

−.296

−.442*

−.364

Significance

.955

.552

.904

.192

.045

.105

LOGDIFF15

Correlation Coefficient

−.040

−.156

−.120

−.307

−.534*

−.448*

Significance

.864

.500

.605

.176

.013

.042

LOGDIFF30

Correlation Coefficient

.084

.079

−.127

−.187

−.100

−.211

Significance

.726

.740

.592

.430

.673

.372

PERC5

Correlation Coefficient

0.000

−.105

.228

−.044

−.062

.013

Significance

1.000

.642

.308

.845

.783

.954

PERC10

Correlation Coefficient

0.000

−.129

.071

−.107

−.296

−.188

Significance

1.000

.568

.752

.636

.181

.402

PERC15

Correlation Coefficient

−.034

−.186

.012

−.225

−.361

−.316

Significance

.881

.408

.958

.315

.099

.152

PERC30

Correlation Coefficient

.190

.179

−.119

.028

.252

−.003

Significance

.396

.426

.596

.903

.258

.990

LOGPERC5

Correlation Coefficient

0.000

−.105

.228

−.044

−.062

.013

Significance

1.000

.642

.308

.845

.783

.954

LOGPERC10

Correlation Coefficient

−.149

−.246

−.007

−.234

−.464*

−.367

Significance

.521

.282

.975

.308

.034

.102

LOGPERC15

Correlation Coefficient

−.186

−.312

−.076

−.363

−.537*

−.514*

Significance

.420

.169

.745

.105

.012

.017

LOGPERC30

Correlation Coefficient

−.019

−.017

−.114

−.096

.016

−.166

Significance

.937

.942

.633

.688

.947

.485

  1. Fluorophotometry values are categorized into 4 major schemes. 1) Increases in fluorescein concentration relative to its baseline at multiple time intervals (5, 10, 15, and 30 min) are labeled ‘DIFF X’ where X represents the minutes. 2) Log values of ‘DIFF X’ are labeled ‘LOGDIFF X.’ 3) Percent changes in fluorescein concentration relative to its baseline at multiple time intervals (5, 10, 15, and 30 min) are labeled ‘PERC X.’ 4) Log values of ‘PERC X’ are labeled ‘LOGPERC X.’
  2. Fluorophotometry scoring schemes are compared with Ocular Surface Disease Index (OSDI), tear break up time (TBUT), fluorescein, and lissamine. OSDI scores were adjusted into quartiles (0–25 = score of 1, 26–50 = score of 2, 51–75 = score of 3, 76–100 = score of 4) and called ‘OSDI Quartiles.’ An aggregate score was calculated by adding OSDI quartiles, TBUT, fluorescein, and lissamine
  3. All significance (p-value) are two-tailed, and p < 0.05 was considered statistically significant. Correlation coefficients and significance are bolded with asterisks* if less than 0.05
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BMC Ophthalmology

ISSN: 1471-2415

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