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Fig. 4 | BMC Ophthalmology

Fig. 4

From: CpG site methylation in CRYAA promoter affect transcription factor Sp1 binding in human lens epithelial cells

Fig. 4

Schematic illustration of the mechanism of DNA methylation of CRYAA in nuclear ARC. Under normal condition, only a few CpG sites are methylated, DNA binds to transcription factors, and CRYAA gene transcription is normal. With aging, the CpG sites of the CRYAA promoter become hypermethylated. Transcription factors, especially Sp1, cannot bind to DNA sequences. Therefore, gene transcription and expression are down-regulated. These procedures are reversible via the DNA demethylation agent Zebularine

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