Association between polymorphisms of OGG1, EPHA2 and age-related cataract risk: a meta-analysis

BMC Ophthalmology

Table 3 Meta-analysis of OGG1 and EPHA2 polymorphisms in ARC based on different genetic models

Comparisons	Total		Cortical cataract		Nuclear cataract		PSC
Comparisons	OR (95 % CI)	P	OR (95 % CI)	P	OR (95 % CI)	P	OR (95 % CI)	P
rs1052133
G vs. C	1.36 (0.99, 1.87)	0.05	1.50 (0.97, 2.32)	0.07	1.23 (0.98, 1.55)	0.07	1.26 (0.94, 1.68)	0.12
GG vs. CC	1.88 (0.96, 3.71)	0.07	2.18 (0.90, 5.28)	0.08	1.45 (0.87, 2.44)	0.16	1.61 (0.83, 3.09)	0.16
CG vs. CC	1.34 (1.06, 1.70)	0.01	1.43 (1.04, 1.96)	0.03	1.32 (0.93, 1.86)	0.12	1.22 (0.79, 1.88)	0.37
GG+CG vs. CC	1.45 (1.16, 1.81)	0.001	1.54 (1.15, 2.07)	0.004	1.37 (0.99, 1.90)	0.06	1.32 (0.88, 1.99)	0.18
GG vs. CG+CC	1.65 (0.82, 3.32)	0.16	1.83 (0.78, 4.29)	0.17	1.18 (0.79, 1.75)	0.43	1.30 (0.78, 2.17)	0.31
rs7543472
T vs. C	1.13 (0.92, 1.38)	0.25	1.16 (1.01, 1.33)	0.03	1.04 (0.75, 1.43)	0.83
TT vs. CC	1.23 (0.99, 1.52)	0.06	1.52 (1.05, 2.18)	0.03	1.08 (0.84, 1.39)	0.55
TC vs. CC	1.06 (0.96, 1.17)	0.22	0.99 (0.82, 1.20)	0.94	1.03 (0.92, 1.15)	0.61
TT+TC vs. CC	1.08 (0.99, 1.19)	0.10	1.06 (0.88, 1.27)	0.53	1.04 (0.93, 1.16)	0.49
TT vs. TC+CC	1.24 (0.90, 1.72)	0.18	1.54 (1.18, 2.01)	0.001	1.11 (0.72, 1.70)	0.63
rs11260867
G vs. C	0.99 (0.89, 1.11)	0.88	0.89 (0.73, 1.07)	0.20	1.09 (0.84, 1.40)	0.52
GG vs. CC	1.14 (0.71, 1.83)	0.59	0.62 (0.31, 1.24)	0.18	1.38 (0.76, 2.49)	0.29
CG vs. CC	1.08 (0.80, 1.47)	0.60	0.66 (0.43, 1.00)	0.05	1.46 (0.95, 2.23)	0.08
GG+CG vs. CC	1.08 (0.80, 1.45)	0.62	0.66 (0.44, 0.99)	0.04	1.43 (0.94, 2.18)	0.09
GG vs. CG+CC	1.16 (0.74, 1.81)	0.52	1.19 (0.55, 2.59)	0.66	0.95 (0.83, 1.10)	0.50

PSC posterior subcapsular cataract, OR odds ratio, 95 % CI 95 % confidence interval

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